Literature DB >> 20010804

Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans.

Raffaella Santoro1, Kerstin-Maike Schmitz, Juan Sandoval, Ingrid Grummt.   

Abstract

Epigenetic silencing of a fraction of ribosomal DNA (rDNA) requires association of the nucleolar chromatin-remodelling complex NoRC to 150-250 nucleotide RNAs (pRNA) that originate from an RNA polymerase I promoter located in the intergenic spacer separating rDNA repeats. Here, we show that NoRC-associated pRNA is transcribed from a sub-fraction of hypomethylated rRNA genes during mid S phase, acting in trans to inherit DNA methylation and transcriptional repression of late-replicating silent rDNA copies. The results reveal variability between individual rDNA clusters with distinct functional consequences.

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Year:  2009        PMID： 20010804      PMCID： PMC2816622          DOI： 10.1038/embor.2009.254

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  20 in total

1.  ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

Authors:  Jian Zhao; Xuejun Yuan; Morten Frödin; Ingrid Grummt
Journal:  Mol Cell       Date:  2003-02       Impact factor: 17.970

2.  The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus.

Authors:  Christine Mayer; Melanie Neubert; Ingrid Grummt
Journal:  EMBO Rep       Date:  2008-07-04       Impact factor: 8.807

3.  The genetic behaviour of a cloned mouse ribosomal DNA segment mimics mouse ribosomal gene evolution.

Authors:  N Arnheim; M Kuehn
Journal:  J Mol Biol       Date:  1979-11-15       Impact factor: 5.469

4.  Multiple repeated units in Drosophila melanogaster ribosomal DNA spacer stimulate rRNA precursor transcription.

Authors:  G Grimaldi; P P Di Nocera
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

5.  Spacer promoters are essential for efficient enhancement of X. laevis ribosomal transcription.

Authors:  R F De Winter; T Moss
Journal:  Cell       Date:  1986-01-31       Impact factor: 41.582

6.  Enhancer-like properties of the 60/81 bp elements in the ribosomal gene spacer of Xenopus laevis.

Authors:  P Labhart; R H Reeder
Journal:  Cell       Date:  1984-05       Impact factor: 41.582

7.  NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines.

Authors:  R Strohner; A Nemeth; P Jansa; U Hofmann-Rohrer; R Santoro; G Längst; I Grummt
Journal:  EMBO J       Date:  2001-09-03       Impact factor: 11.598

8.  An RNA polymerase I promoter located in the CHO and mouse ribosomal DNA spacers: functional analysis and factor and sequence requirements.

Authors:  J Tower; S L Henderson; K M Dougherty; P J Wejksnora; B Sollner-Webb
Journal:  Mol Cell Biol       Date:  1989-04       Impact factor: 4.272

9.  The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription.

Authors:  Raffaella Santoro; Junwei Li; Ingrid Grummt
Journal:  Nat Genet       Date:  2002-10-07       Impact factor: 38.330

10.  A novel promoter in the mouse rDNA spacer is active in vivo and in vitro.

Authors:  A Kuhn; I Grummt
Journal:  EMBO J       Date:  1987-11       Impact factor: 11.598
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  46 in total

Review 1.  The nucleolus.

Authors:  Thoru Pederson
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-03-01       Impact factor: 10.005

2.  Expression of variant ribosomal RNA genes in mouse oocytes and preimplantation embryos.

Authors:  Motomasa Ihara; Hung Tseng; Richard M Schultz
Journal:  Biol Reprod       Date:  2011-01-05       Impact factor: 4.285

Review 3.  Nucleolar DNA: the host and the guests.

Authors:  E Smirnov; D Cmarko; T Mazel; M Hornáček; I Raška
Journal:  Histochem Cell Biol       Date:  2016-02-04       Impact factor: 4.304

4.  Neurodegeneration-associated instability of ribosomal DNA.

Authors:  Justin Hallgren; Maciej Pietrzak; Grzegorz Rempala; Peter T Nelson; Michal Hetman
Journal:  Biochim Biophys Acta       Date:  2014-01-02

Review 5.  Noisy silence: non-coding RNA and heterochromatin formation at repetitive elements.

Authors:  Holger Bierhoff; Anna Postepska-Igielska; Ingrid Grummt
Journal:  Epigenetics       Date:  2013-10-11       Impact factor: 4.528

6.  Life time of some RNA products of rDNA intergenic spacer in HeLa cells.

Authors:  T Vacík; S Kereïche; I Raška; D Cmarko; E Smirnov
Journal:  Histochem Cell Biol       Date:  2019-07-25       Impact factor: 4.304

7.  The RNA helicase DHX9 establishes nucleolar heterochromatin, and this activity is required for embryonic stem cell differentiation.

Authors:  Sergio Leone; Dominik Bär; Coenraad Frederik Slabber; Damian Dalcher; Raffaella Santoro
Journal:  EMBO Rep       Date:  2017-06-06       Impact factor: 8.807

Review 8.  Chromatin loops and causality loops: the influence of RNA upon spatial nuclear architecture.

Authors:  Iain A Sawyer; Miroslav Dundr
Journal:  Chromosoma       Date:  2017-06-07       Impact factor: 4.316

9.  A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.

Authors:  Irina Anosova; Svitlana Melnik; Konstantinos Tripsianes; Fatiha Kateb; Ingrid Grummt; Michael Sattler
Journal:  Nucleic Acids Res       Date:  2015-04-27       Impact factor: 16.971

10.  CTCF regulates the local epigenetic state of ribosomal DNA repeats.

Authors:  Suzanne van de Nobelen; Manuel Rosa-Garrido; Joerg Leers; Helen Heath; Widia Soochit; Linda Joosen; Iris Jonkers; Jeroen Demmers; Michael van der Reijden; Verónica Torrano; Frank Grosveld; M Dolores Delgado; Rainer Renkawitz; Niels Galjart; Frank Sleutels
Journal:  Epigenetics Chromatin       Date:  2010-11-08       Impact factor: 4.954
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