Literature DB >> 20010712

Ligand functional selectivity advances our understanding of drug mechanisms and drug discovery.

Richard B Mailman1, Vishakantha Murthy.   

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Year:  2010        PMID： 20010712      PMCID： PMC2952437          DOI： 10.1038/npp.2009.117

Source DB:  PubMed          Journal:  Neuropsychopharmacology        ISSN： 0893-133X            Impact factor:   7.853


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  5 in total

Review 1.  Functional selectivity and classical concepts of quantitative pharmacology.

Authors:  Jonathan D Urban; William P Clarke; Mark von Zastrow; David E Nichols; Brian Kobilka; Harel Weinstein; Jonathan A Javitch; Bryan L Roth; Arthur Christopoulos; Patrick M Sexton; Keith J Miller; Michael Spedding; Richard B Mailman
Journal:  J Pharmacol Exp Ther       Date:  2006-06-27       Impact factor: 4.030

Review 2.  GPCR functional selectivity has therapeutic impact.

Authors:  Richard B Mailman
Journal:  Trends Pharmacol Sci       Date:  2007-07-13       Impact factor: 14.819

3.  Locomotor inhibition, yawning and vacuous chewing induced by a novel dopamine D2 post-synaptic receptor agonist.

Authors:  H P Smith; D E Nichols; R B Mailman; C P Lawler
Journal:  Eur J Pharmacol       Date:  1997-03-26       Impact factor: 4.432

4.  Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs.

Authors:  Jason D Kilts; Hilary S Connery; Elaine G Arrington; Mechelle M Lewis; Cindy P Lawler; Gerry S Oxford; Karen L O'Malley; Richard D Todd; Bonita L Blake; David E Nichols; Richard B Mailman
Journal:  J Pharmacol Exp Ther       Date:  2002-06       Impact factor: 4.030

5.  Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.

Authors:  Xi-Ping Huang; Vincent Setola; Prem N Yadav; John A Allen; Sarah C Rogan; Bonnie J Hanson; Chetana Revankar; Matt Robers; Chris Doucette; Bryan L Roth
Journal:  Mol Pharmacol       Date:  2009-07-01       Impact factor: 4.436
  5 in total
  7 in total

1.  PharmGKB summary: dopamine receptor D2.

Authors:  Huaiyu Mi; Paul D Thomas; Huijun Z Ring; Ruhong Jiang; Katrin Sangkuhl; Teri E Klein; Russ B Altman
Journal:  Pharmacogenet Genomics       Date:  2011-06       Impact factor: 2.089

2.  Sensing conformational changes in metabotropic glutamate receptors.

Authors:  Marie-Laure Rives; Jonathan A Javitch
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-29       Impact factor: 11.205

3.  Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues.

Authors:  Cécile Béguin; Justin Potuzak; Wei Xu; Lee-Yuan Liu-Chen; John M Streicher; Chad E Groer; Laura M Bohn; William A Carlezon; Bruce M Cohen
Journal:  Bioorg Med Chem Lett       Date:  2011-12-07       Impact factor: 2.823

4.  Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D1 Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms.

Authors:  Yang Yang; Susan D Kocher; Mechelle M Lewis; Richard B Mailman
Journal:  Front Neurosci       Date:  2022-06-16       Impact factor: 5.152

Review 5.  Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia.

Authors:  Amy F T Arnsten; Ragy R Girgis; David L Gray; Richard B Mailman
Journal:  Biol Psychiatry       Date:  2016-01-18       Impact factor: 13.382

6.  Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma.

Authors:  Ma Reina D Improgo; Christopher W Johnson; Andrew R Tapper; Paul D Gardner
Journal:  PLoS One       Date:  2011-09-08       Impact factor: 3.240

Review 7.  Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism.

Authors:  Andrea de Bartolomeis; Carmine Tomasetti; Felice Iasevoli
Journal:  CNS Drugs       Date:  2015-09       Impact factor: 5.749
  7 in total

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