Literature DB >> 20010095

Creating and curing fatty hearts.

Raffay S Khan1, Konstaninos Drosatos, Ira J Goldberg.   

Abstract

PURPOSE OF REVIEW: Diseases associated with ectopic disposition of lipids are becoming an increasingly important medical problem as the incidence of type 2 diabetes and obesity increases. One of the organs affected by lipotoxicity is the heart and this review presents an update on human and animal studies of this problem. RECENT
FINDINGS: Human studies have clearly correlated heart dysfunction with the content of triglyceride. More recently human heart samples have been used to assess gene changes associated with altered lipid accumulation. Genetically altered mice have been created that develop lipotoxic cardiomyopathies and newer investigations are attempting to delineate curative therapies.
SUMMARY: Human studies will confirm the metabolic changes associated with lipotoxic cardiomyopathy and, hopefully, animal studies will guide treatment options.

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Year:  2010        PMID： 20010095      PMCID： PMC5628503          DOI： 10.1097/MCO.0b013e3283357272

Source DB:  PubMed          Journal:  Curr Opin Clin Nutr Metab Care        ISSN： 1363-1950            Impact factor:   4.294


  22 in total

1.  Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity.

Authors:  Jie Yan; Martin E Young; Lei Cui; Gary D Lopaschuk; Ronglih Liao; Rong Tian
Journal:  Circulation       Date:  2009-05-18       Impact factor: 29.690

2.  Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice.

Authors:  So-Young Park; You-Ree Cho; Hyo-Jeong Kim; Takamasa Higashimori; Cheryl Danton; Mi-Kyung Lee; Asim Dey; Beverly Rothermel; Young-Bum Kim; April Kalinowski; Kerry S Russell; Jason K Kim
Journal:  Diabetes       Date:  2005-12       Impact factor: 9.461

3.  Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury.

Authors:  Jason R B Dyck; Teresa A Hopkins; Sebastien Bonnet; Evangelos D Michelakis; Martin E Young; Miho Watanabe; Yosuke Kawase; Kou-ichi Jishage; Gary D Lopaschuk
Journal:  Circulation       Date:  2006-10-09       Impact factor: 29.690

4.  Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids.

Authors:  Hiroshi Irie; Irvin B Krukenkamp; Joep F F Brinkmann; Glenn R Gaudette; Adam E Saltman; William Jou; Jan F C Glatz; Nada A Abumrad; Azeddine Ibrahimi
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-13       Impact factor: 11.205

5.  Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis.

Authors:  Brendan N Reid; Gene P Ables; Oleg A Otlivanchik; Gabriele Schoiswohl; Rudolf Zechner; William S Blaner; Ira J Goldberg; Robert F Schwabe; Streamson C Chua; Li-Shin Huang
Journal:  J Biol Chem       Date:  2008-03-12       Impact factor: 5.157

6.  Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice.

Authors:  Masami Ueno; Jinya Suzuki; Yasuo Zenimaru; Sadao Takahashi; Tsutomu Koizumi; Sakon Noriki; Osamu Yamaguchi; Kinya Otsu; Wen-Jun Shen; Fredric B Kraemer; Isamu Miyamori
Journal:  Am J Physiol Endocrinol Metab       Date:  2008-04-15       Impact factor: 4.310

7.  Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome.

Authors:  Raffaele Marfella; Clara Di Filippo; Michele Portoghese; Michelangela Barbieri; Franca Ferraraccio; Mario Siniscalchi; Federico Cacciapuoti; Francesco Rossi; Michele D'Amico; Giuseppe Paolisso
Journal:  J Lipid Res       Date:  2009-05-24       Impact factor: 5.922

8.  CD36 deficiency rescues lipotoxic cardiomyopathy.

Authors:  John Yang; Nandakumar Sambandam; Xianlin Han; Richard W Gross; Michael Courtois; Attila Kovacs; Maria Febbraio; Brian N Finck; Daniel P Kelly
Journal:  Circ Res       Date:  2007-03-15       Impact factor: 17.367

9.  Ceramide is a cardiotoxin in lipotoxic cardiomyopathy.

Authors:  Tae-Sik Park; Yunying Hu; Hye-Lim Noh; Konstantinos Drosatos; Kazue Okajima; Jonathan Buchanan; Joseph Tuinei; Shunichi Homma; Xian-Cheng Jiang; E Dale Abel; Ira J Goldberg
Journal:  J Lipid Res       Date:  2008-05-30       Impact factor: 5.922

10.  Cardiac metabolic compensation to hypertension requires lipoprotein lipase.

Authors:  Haruyo Yamashita; Kalyani G Bharadwaj; Shota Ikeda; Tae-Sik Park; Ira J Goldberg
Journal:  Am J Physiol Endocrinol Metab       Date:  2008-07-22       Impact factor: 4.310
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  16 in total

1.  Fatty acids identified in the Burmese python promote beneficial cardiac growth.

Authors:  Cecilia A Riquelme; Jason A Magida; Brooke C Harrison; Christopher E Wall; Thomas G Marr; Stephen M Secor; Leslie A Leinwand
Journal:  Science       Date:  2011-10-28       Impact factor: 47.728

2.  Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction.

Authors:  Petra C Kienesberger; Thomas Pulinilkunnil; Miranda M Y Sung; Jeevan Nagendran; Guenter Haemmerle; Erin E Kershaw; Martin E Young; Peter E Light; Gavin Y Oudit; Rudolf Zechner; Jason R B Dyck
Journal:  Mol Cell Biol       Date:  2011-12-12       Impact factor: 4.272

3.  Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation.

Authors:  Konstantinos Drosatos; Kalyani G Bharadwaj; Anastasios Lymperopoulos; Shota Ikeda; Raffay Khan; Yunying Hu; Rajiv Agarwal; Shuiqing Yu; Hongfeng Jiang; Susan F Steinberg; William S Blaner; Walter J Koch; Ira J Goldberg
Journal:  Am J Physiol Endocrinol Metab       Date:  2010-12-07       Impact factor: 4.310

4.  Male-Specific Cardiac Dysfunction in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)-Deficient Mice.

Authors:  Poulami Basu; Faisal J Alibhai; Elena V Tsimakouridze; Ratnesh K Singh; Sabina Paglialunga; Graham P Holloway; Tami A Martino; Marica Bakovic
Journal:  Mol Cell Biol       Date:  2015-05-18       Impact factor: 4.272

5.  Macrophages modulate cardiac function in lipotoxic cardiomyopathy.

Authors:  Joel D Schilling; Heather M Machkovech; Alfred H J Kim; Reto Schwendener; Reto Schwedwener; Jean E Schaffer
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-10-05       Impact factor: 4.733

6.  High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance.

Authors:  Anisha A Gupte; Laurie J Minze; Maricela Reyes; Yuelan Ren; Xukui Wang; Gerd Brunner; Mohamad Ghosn; Andrea M Cordero-Reyes; Karen Ding; Domenico Pratico; Joel Morrisett; Zheng-Zheng Shi; Dale J Hamilton; Christopher J Lyon; Willa A Hsueh
Journal:  Endocrinology       Date:  2013-05-24       Impact factor: 4.736

7.  Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation.

Authors:  Petra C Kienesberger; Thomas Pulinilkunnil; Jeevan Nagendran; Martin E Young; Juliane G Bogner-Strauss; Hubert Hackl; Rammy Khadour; Emma Heydari; Guenter Haemmerle; Rudolf Zechner; Erin E Kershaw; Jason R B Dyck
Journal:  Cardiovasc Res       Date:  2013-05-25       Impact factor: 10.787

8.  Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction.

Authors:  Hong Wang; Urmila Sreenivasan; Da-Wei Gong; Kelly A O'Connell; Erinne R Dabkowski; Peter A Hecker; Nicoleta Ionica; Manige Konig; Anup Mahurkar; Yezhou Sun; William C Stanley; Carole Sztalryd
Journal:  J Lipid Res       Date:  2013-01-23       Impact factor: 5.922

9.  Measurements of diacylglycerols in skeletal muscle by atmospheric pressure chemical ionization mass spectrometry.

Authors:  Su-Yeon Lee; Jung Ran Kim; Mi-Young Ha; Soon-Mi Shim; Tae-Sik Park
Journal:  Lipids       Date:  2013-02-08       Impact factor: 1.880

10.  Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesity.

Authors:  T Pulinilkunnil; P C Kienesberger; J Nagendran; N Sharma; M E Young; J R B Dyck
Journal:  Int J Obes (Lond)       Date:  2013-06-05       Impact factor: 5.095
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