Literature DB >> 20009954

Randomized clinical trials in stroke research.

Chul Ahn1, Daniel Ahn.   

Abstract

A randomized clinical trial is widely regarded as the most rigorous study design to determine the efficacy of intervention because spurious causality and bias associated with other experimental designs can be avoided. The purpose of this article is to provide clinicians and clinical researchers the types of randomized clinical trials used in stroke studies and to discuss the advantages and the limitations for each type of randomized stroke clinical trials.

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Year:  2010        PMID： 20009954      PMCID： PMC2837939          DOI： 10.2310/JIM.0b013e3181c9b2d4

Source DB:  PubMed          Journal:  J Investig Med        ISSN： 1081-5589            Impact factor:   2.895


  28 in total

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Authors:  J O'Quigley; M Pepe; L Fisher
Journal:  Biometrics       Date:  1990-03       Impact factor: 2.571

2.  Randomization in clinical trials: conclusions and recommendations.

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Journal:  Control Clin Trials       Date:  1988-12

3.  Randomized consent designs for clinical trials: an update.

Authors:  M Zelen
Journal:  Stat Med       Date:  1990-06       Impact factor: 2.373

4.  Long-term angiotensin-converting enzyme inhibitor perindopril therapy improves cerebral perfusion reserve in patients with previous minor stroke.

Authors:  Jun Hatazawa; Eku Shimosegawa; Yasuhiro Osaki; Masanobu Ibaraki; Naohiko Oku; Shinji Hasegawa; Ken Nagata; Yutaka Hirata; Yuko Miura
Journal:  Stroke       Date:  2004-07-15       Impact factor: 7.914

5.  High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART).

Authors:  Mitchell S V Elkind; Ralph L Sacco; Robert B Macarthur; Ellinor Peerschke; Greg Neils; Howard Andrews; Joshua Stillman; Tania Corporan; Dana Leifer; Rui Liu; Ken Cheung
Journal:  Cerebrovasc Dis       Date:  2009-07-16       Impact factor: 2.762

6.  Final report on the aspirin component of the ongoing Physicians' Health Study.

Authors: 
Journal:  N Engl J Med       Date:  1989-07-20       Impact factor: 91.245

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Journal:  N Engl J Med       Date:  1978-07-13       Impact factor: 91.245

8.  A new design for randomized clinical trials.

Authors:  M Zelen
Journal:  N Engl J Med       Date:  1979-05-31       Impact factor: 91.245

9.  ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group.

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Journal:  Lancet       Date:  1995-03-18       Impact factor: 79.321

10.  Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design.

Authors:  R Peto; M C Pike; P Armitage; N E Breslow; D R Cox; S V Howard; N Mantel; K McPherson; J Peto; P G Smith
Journal:  Br J Cancer       Date:  1976-12       Impact factor: 7.640
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  3 in total

1.  Outcomes of community-based differentiated models of multi-month dispensing of antiretroviral medication among stable HIV-infected patients in Lesotho: a cluster randomised non-inferiority trial protocol.

Authors:  I O Faturiyele; T Appolinare; N Ngorima-Mabhena; G Fatti; I Tshabalala; V J Tukei; P T Pisa
Journal:  BMC Public Health       Date:  2018-08-29       Impact factor: 3.295

2.  Caregiver-mediated exercises with e-health support for early supported discharge after stroke (CARE4STROKE): A randomized controlled trial.

Authors:  Judith D M Vloothuis; Marijn Mulder; Rinske H M Nijland; Quirine S Goedhart; Manin Konijnenbelt; Henry Mulder; Cees M P M Hertogh; Maurits van Tulder; Erwin E H van Wegen; Gert Kwakkel
Journal:  PLoS One       Date:  2019-04-08       Impact factor: 3.240

3.  Japan Diabetes Outcome Intervention Trial-1 (J-DOIT1), a nationwide cluster randomized trial of type 2 diabetes prevention by telephone-delivered lifestyle support for high-risk subjects detected at health checkups: rationale, design, and recruitment.

Authors:  Naoki Sakane; Kazuhiko Kotani; Kaoru Takahashi; Yoshiko Sano; Kokoro Tsuzaki; Kentaro Okazaki; Juichi Sato; Sadao Suzuki; Satoshi Morita; Kazuo Izumi; Masayuki Kato; Naoki Ishizuka; Mitsuhiko Noda; Hideshi Kuzuya
Journal:  BMC Public Health       Date:  2013-01-29       Impact factor: 3.295
  3 in total

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