BACKGROUND AND AIMS: Nitric oxide (NO) may play a critical role in facilitating the delivery of blood to active skeletal muscle, ultimately impacting functional health in older adults. Plasma nitrite is a useful marker of vascular NO bioavailability. The aim of the current investigation was to examine the effect of a widely used physical function test on plasma nitrite concentrations in older adults. METHODS: Venous blood was drawn before, immediately following, and 10 minutes following the completion of a 400-m walk test. Blood samples were added to heparin and frozen for subsequent analysis of nitrite levels using chemiluminescence. RESULTS: Twenty six (79±4 yrs) women participated in this study. Plasma nitrite levels decreased approximately 22% from baseline following a 400-m walk. Percent change in plasma nitrite was related to walking speed (r=-0.550, p=0.004). CONCLUSIONS: These data suggest an alteration in plasma nitrite concentration following a functional test which may impact functional health.
BACKGROUND AND AIMS: Nitric oxide (NO) may play a critical role in facilitating the delivery of blood to active skeletal muscle, ultimately impacting functional health in older adults. Plasma nitrite is a useful marker of vascular NO bioavailability. The aim of the current investigation was to examine the effect of a widely used physical function test on plasma nitrite concentrations in older adults. METHODS:Venous blood was drawn before, immediately following, and 10 minutes following the completion of a 400-m walk test. Blood samples were added to heparin and frozen for subsequent analysis of nitrite levels using chemiluminescence. RESULTS: Twenty six (79±4 yrs) women participated in this study. Plasma nitrite levels decreased approximately 22% from baseline following a 400-m walk. Percent change in plasma nitrite was related to walking speed (r=-0.550, p=0.004). CONCLUSIONS: These data suggest an alteration in plasma nitrite concentration following a functional test which may impact functional health.
Authors: T Lauer; M Preik; T Rassaf; B E Strauer; A Deussen; M Feelisch; M Kelm Journal: Proc Natl Acad Sci U S A Date: 2001-10-16 Impact factor: 11.205
Authors: Kenyatta Cosby; Kristine S Partovi; Jack H Crawford; Rakesh P Patel; Christopher D Reiter; Sabrina Martyr; Benjamin K Yang; Myron A Waclawiw; Gloria Zalos; Xiuli Xu; Kris T Huang; Howard Shields; Daniel B Kim-Shapiro; Alan N Schechter; Richard O Cannon; Mark T Gladwin Journal: Nat Med Date: 2003-11-02 Impact factor: 53.440
Authors: Donald H Paterson; Devin Govindasamy; Marjan Vidmar; David A Cunningham; John J Koval Journal: J Am Geriatr Soc Date: 2004-10 Impact factor: 5.562
Authors: Stephen P Sayers; Alan M Jette; Stephen M Haley; Tim C Heeren; Jack M Guralnik; Roger A Fielding Journal: J Am Geriatr Soc Date: 2004-09 Impact factor: 5.562