Literature DB >> 20008332

Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway.

Chunming Liu1, Xi He.   

Abstract

A new study in Nature has identified a small molecule inhibitor for the oncogenic Wnt/beta-catenin pathway that is responsible for many human cancers. This inhibitor targets an unsuspected cellular enzyme, Tankyrase, which controls the destruction of a beta-catenin destructor.

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Year:  2009        PMID： 20008332      PMCID： PMC2861491          DOI： 10.1093/jmcb/mjp040

Source DB:  PubMed          Journal:  J Mol Cell Biol        ISSN： 1759-4685            Impact factor:   6.216


  16 in total

Review 1.  Wnt signaling and cancer.

Authors:  P Polakis
Journal:  Genes Dev       Date:  2000-08-01       Impact factor: 11.361

2.  Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity.

Authors:  Nicholas S Tolwinski; Marcel Wehrli; Anna Rives; Naz Erdeniz; Stephen DiNardo; Eric Wieschaus
Journal:  Dev Cell       Date:  2003-03       Impact factor: 12.270

Review 3.  Wnt/beta-catenin signaling in development and disease.

Authors:  Hans Clevers
Journal:  Cell       Date:  2006-11-03       Impact factor: 41.582

4.  Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.

Authors:  J Behrens; B A Jerchow; M Würtele; J Grimm; C Asbrand; R Wirtz; M Kühl; D Wedlich; W Birchmeier
Journal:  Science       Date:  1998-04-24       Impact factor: 47.728

Review 5.  Lessons from hereditary colorectal cancer.

Authors:  K W Kinzler; B Vogelstein
Journal:  Cell       Date:  1996-10-18       Impact factor: 41.582

Review 6.  Mining the Wnt pathway for cancer therapeutics.

Authors:  Nick Barker; Hans Clevers
Journal:  Nat Rev Drug Discov       Date:  2006-12       Impact factor: 84.694

7.  A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected].

Authors:  Katayoon H Emami; Cu Nguyen; Hong Ma; Dae Hoon Kim; Kwang Won Jeong; Masakatsu Eguchi; Randall T Moon; Jia-Ling Teo; Se Woong Oh; Hak Yeop Kim; Sung Hwan Moon; Jong Ryul Ha; Michael Kahn
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-16       Impact factor: 11.205

8.  Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

Authors:  Shih-Min A Huang; Yuji M Mishina; Shanming Liu; Atwood Cheung; Frank Stegmeier; Gregory A Michaud; Olga Charlat; Elizabeth Wiellette; Yue Zhang; Stephanie Wiessner; Marc Hild; Xiaoying Shi; Christopher J Wilson; Craig Mickanin; Vic Myer; Aleem Fazal; Ronald Tomlinson; Fabrizio Serluca; Wenlin Shao; Hong Cheng; Michael Shultz; Christina Rau; Markus Schirle; Judith Schlegl; Sonja Ghidelli; Stephen Fawell; Chris Lu; Daniel Curtis; Marc W Kirschner; Christoph Lengauer; Peter M Finan; John A Tallarico; Tewis Bouwmeester; Jeffery A Porter; Andreas Bauer; Feng Cong
Journal:  Nature       Date:  2009-09-16       Impact factor: 49.962

9.  Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex.

Authors:  Maina Lepourcelet; Ying-Nan P Chen; Dennis S France; Huisheng Wang; Phillip Crews; Frank Petersen; Charles Bruseo; Alexander W Wood; Ramesh A Shivdasani
Journal:  Cancer Cell       Date:  2004-01       Impact factor: 31.743

10.  The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway.

Authors:  Ethan Lee; Adrian Salic; Roland Krüger; Reinhart Heinrich; Marc W Kirschner
Journal:  PLoS Biol       Date:  2003-10-13       Impact factor: 8.029
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  10 in total

1.  An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors.

Authors:  Wen Zhang; Vitaliy M Sviripa; Liliia M Kril; Tianxin Yu; Yanqi Xie; W Brad Hubbard; Patrick G Sullivan; Xi Chen; Chang-Guo Zhan; Yang Yang-Hartwich; B Mark Evers; Brett T Spear; Roberto Gedaly; David S Watt; Chunming Liu
Journal:  J Med Chem       Date:  2019-12-16       Impact factor: 7.446

2.  Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo.

Authors:  Lihui Qian; James P Mahaffey; Heather L Alcorn; Kathryn V Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2011-05-09       Impact factor: 11.205

3.  Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression.

Authors:  Wen Zhang; Vitaliy Sviripa; Liliia M Kril; Xi Chen; Tianxin Yu; Jiandang Shi; Piotr Rychahou; B Mark Evers; David S Watt; Chunming Liu
Journal:  J Med Chem       Date:  2011-02-03       Impact factor: 7.446

Review 4.  Toggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexes.

Authors:  Ofelia Tacchelly-Benites; Zhenghan Wang; Eungi Yang; Ethan Lee; Yashi Ahmed
Journal:  Bioessays       Date:  2013-09-19       Impact factor: 4.345

5.  A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in Drosophila.

Authors:  Zhenghan Wang; Ofelia Tacchelly-Benites; Geoffrey P Noble; Megan K Johnson; Jean-Philippe Gagné; Guy G Poirier; Yashi Ahmed
Journal:  Genetics       Date:  2018-12-28       Impact factor: 4.562

6.  Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.

Authors:  Renyue Bao; Tania Christova; Siyuan Song; Stephane Angers; Xiaojun Yan; Liliana Attisano
Journal:  PLoS One       Date:  2012-11-07       Impact factor: 3.240

Review 7.  Materials from peptide assembly: towards the treatment of cancer and transmittable disease.

Authors:  Monica C Branco; Dina M Sigano; Joel P Schneider
Journal:  Curr Opin Chem Biol       Date:  2011-04-18       Impact factor: 8.822

8.  Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity.

Authors:  Nina Marie Pedersen; Tor Espen Thorvaldsen; Sebastian Wolfgang Schultz; Eva Maria Wenzel; Harald Stenmark
Journal:  PLoS One       Date:  2016-08-02       Impact factor: 3.240

9.  Wnt pathway activation by ADP-ribosylation.

Authors:  Eungi Yang; Ofelia Tacchelly-Benites; Zhenghan Wang; Michael P Randall; Ai Tian; Hassina Benchabane; Sarah Freemantle; Claudio Pikielny; Nicholas S Tolwinski; Ethan Lee; Yashi Ahmed
Journal:  Nat Commun       Date:  2016-05-03       Impact factor: 14.919

10.  Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta.

Authors:  Estefania Martino-Echarri; Mariana G Brocardo; Kate M Mills; Beric R Henderson
Journal:  PLoS One       Date:  2016-03-01       Impact factor: 3.240
  10 in total

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