Mazen Y El-Zibdeh1, Lama T Yousef. 1. Department of Obstetrics and Gynaecology, Islamic Hospital, Amman, Jordan. drmazen@go.com.jo
Abstract
INTRODUCTION: The aim of this study was to determine whether dydrogesterone helps to preserve pregnancy in women with threatened miscarriage. METHODS:146 women who presented with mild or moderate vaginal bleeding during the first trimester of pregnancy were randomised to receive oral dydrogesterone (10mg b.i.d.) (n=86) or no treatment (n=60). Dydrogesterone was continued until 1 week after the bleeding had stopped. All women received standard supportive care. RESULTS: The incidence of miscarriage was significantly lower in the dydrogesterone group than in the untreated group (17.5% vs. 25%; p<0.05). There were no statistically significant differences between the groups with respect to pregnancy complications or congenital abnormalities. CONCLUSION:Dydrogesterone appears to have beneficial effects in women with threatened miscarriage. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
RCT Entities:
INTRODUCTION: The aim of this study was to determine whether dydrogesterone helps to preserve pregnancy in women with threatened miscarriage. METHODS: 146 women who presented with mild or moderate vaginal bleeding during the first trimester of pregnancy were randomised to receive oral dydrogesterone (10mg b.i.d.) (n=86) or no treatment (n=60). Dydrogesterone was continued until 1 week after the bleeding had stopped. All women received standard supportive care. RESULTS: The incidence of miscarriage was significantly lower in the dydrogesterone group than in the untreated group (17.5% vs. 25%; p<0.05). There were no statistically significant differences between the groups with respect to pregnancy complications or congenital abnormalities. CONCLUSION:Dydrogesterone appears to have beneficial effects in women with threatened miscarriage. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
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