BACKGROUND AND PURPOSE: The oncologic outcomes of extraperitoneal (EP) rectal cancer are known to differ from those of intraperitoneal (IP) rectal cancer; however, these differences have not been studied in rectal patients treated by preoperative chemoradiotherapy (CRT). The aim of this study is to evaluate the prognostic impact of peritonealisation in rectal patients treated by preoperative CRT. MATERIALS AND METHODS: This study analyzed the data of 362 patients who received preoperative CRT and underwent curative surgery for locally advanced rectal cancer at 3-9 cm above the anal verge. Patients were categorised into EP and IP groups based on whether peritonealisation was present, according to pathology reports. The oncologic outcomes between the two groups were compared. RESULTS: Peritonealisation was absent in 330 patients and present in 32 patients. In univariate analysis, disease-free survival was significantly worse in the EP group than in the IP group (73.0% versus 93.5%, p=0.035). Multivariate analysis revealed the following independent risk factors for recurrence: the absence of peritonealisation (p=0.023), ypT stage (p=0.015) and ypN stage (p<.0001). CONCLUSIONS: Peritonealisation of rectal cancer may be a prognostic factor of disease-free survival in patients with rectal cancer treated by preoperative CRT and surgery. (c) 2009 Elsevier Ireland Ltd. All rights reserved.
BACKGROUND AND PURPOSE: The oncologic outcomes of extraperitoneal (EP) rectal cancer are known to differ from those of intraperitoneal (IP) rectal cancer; however, these differences have not been studied in rectal patients treated by preoperative chemoradiotherapy (CRT). The aim of this study is to evaluate the prognostic impact of peritonealisation in rectal patients treated by preoperative CRT. MATERIALS AND METHODS: This study analyzed the data of 362 patients who received preoperative CRT and underwent curative surgery for locally advanced rectal cancer at 3-9 cm above the anal verge. Patients were categorised into EP and IP groups based on whether peritonealisation was present, according to pathology reports. The oncologic outcomes between the two groups were compared. RESULTS: Peritonealisation was absent in 330 patients and present in 32 patients. In univariate analysis, disease-free survival was significantly worse in the EP group than in the IP group (73.0% versus 93.5%, p=0.035). Multivariate analysis revealed the following independent risk factors for recurrence: the absence of peritonealisation (p=0.023), ypT stage (p=0.015) and ypN stage (p<.0001). CONCLUSIONS: Peritonealisation of rectal cancer may be a prognostic factor of disease-free survival in patients with rectal cancer treated by preoperative CRT and surgery. (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Authors: Olga A Lavryk; Elena Manilich; Michael A Valente; Arshiya Miriam; Emre Gorgun; Matthew F Kalady; Sherief Shawki; Conor P Delaney; Scott R Steele Journal: Int J Colorectal Dis Date: 2019-11-27 Impact factor: 2.571
Authors: Byoung Chul Lee; In Ja Park; Chan Wook Kim; Seok-Byung Lim; Chang Sik Yu; Jin Cheon Kim Journal: Ann Surg Treat Res Date: 2017-03-24 Impact factor: 1.859
Authors: Seung-Gu Yeo; Min-Jeong Kim; Dae Yong Kim; Hee Jin Chang; Min Ju Kim; Ji Yeon Baek; Sun Young Kim; Tae Hyun Kim; Ji Won Park; Jae Hwan Oh Journal: Radiat Oncol Date: 2013-05-06 Impact factor: 3.481