PURPOSE: That circulating soluble form of intercellular adhesion molecule-1 (sICAM-1) is associated with an increased risk for coronary artery disease is well recognized. However, information is scant regarding the distribution and cardiovascular (CV) risk correlates of sICAM-1 in asymptomatic young adults. METHODS: Plasma sICAM-1 was measured in 1,184 black and white persons in the Bogalusa Heart Study cohort (70% white, 43% male), aged 24 to 44 years. CV risk was assessed in terms of CV risk factors, status of parental CV disease, and composite carotid intima-media thickness (IMT). RESULTS: sICAM-1 levels displayed race difference (whites > blacks, p<0.0001), but no sex difference. In multivariate analysis including age, race, sex, smoking status, waist circumference, mean arterial pressure, low- and high-density lipoprotein (LDL and HDL) cholesterols, triglycerides, insulin resistance index, C-reactive protein (CRP), and adiponectin, the significant predictors of sICAM-1, in order of entry, were race (white > black), smoking, CRP, and waist circumference. Furthermore, there was a smoking by waist circumference interaction in that smoking attenuated the magnitude of correlation between waist circumference and sICAM-1. Levels of sICAM-1 adjusted for age, race, sex, and smoking increased with number of metabolic syndrome components (p for trend<0.01); positive family history of CV disease (p<0.05); and increased in composite carotid IMT specific for age, race, and sex (p for trend<0.05). CONCLUSION: These findings underscore the potential value of plasma sICAM-1 as an additional biomarker for CV risk among asymptomatic young adults.
PURPOSE: That circulating soluble form of intercellular adhesion molecule-1 (sICAM-1) is associated with an increased risk for coronary artery disease is well recognized. However, information is scant regarding the distribution and cardiovascular (CV) risk correlates of sICAM-1 in asymptomatic young adults. METHODS: Plasma sICAM-1 was measured in 1,184 black and white persons in the Bogalusa Heart Study cohort (70% white, 43% male), aged 24 to 44 years. CV risk was assessed in terms of CV risk factors, status of parental CV disease, and composite carotid intima-media thickness (IMT). RESULTS: sICAM-1 levels displayed race difference (whites > blacks, p<0.0001), but no sex difference. In multivariate analysis including age, race, sex, smoking status, waist circumference, mean arterial pressure, low- and high-density lipoprotein (LDL and HDL) cholesterols, triglycerides, insulin resistance index, C-reactive protein (CRP), and adiponectin, the significant predictors of sICAM-1, in order of entry, were race (white > black), smoking, CRP, and waist circumference. Furthermore, there was a smoking by waist circumference interaction in that smoking attenuated the magnitude of correlation between waist circumference and sICAM-1. Levels of sICAM-1 adjusted for age, race, sex, and smoking increased with number of metabolic syndrome components (p for trend<0.01); positive family history of CV disease (p<0.05); and increased in composite carotid IMT specific for age, race, and sex (p for trend<0.05). CONCLUSION: These findings underscore the potential value of plasma sICAM-1 as an additional biomarker for CV risk among asymptomatic young adults.
Authors: Clara C Elbers; Yiran Guo; Vinicius Tragante; Erik P A van Iperen; Matthew B Lanktree; Berta Almoguera Castillo; Fang Chen; Lisa R Yanek; Mary K Wojczynski; Yun R Li; Bart Ferwerda; Christie M Ballantyne; Sarah G Buxbaum; Yii-Der Ida Chen; Wei-Min Chen; L Adrienne Cupples; Mary Cushman; Yanan Duan; David Duggan; Michele K Evans; Jyotika K Fernandes; Myriam Fornage; Melissa Garcia; W Timothy Garvey; Nicole Glazer; Felicia Gomez; Tamara B Harris; Indrani Halder; Virginia J Howard; Margaux F Keller; M Ilyas Kamboh; Charles Kooperberg; Stephen B Kritchevsky; Andrea LaCroix; Kiang Liu; Yongmei Liu; Kiran Musunuru; Anne B Newman; N Charlotte Onland-Moret; Jose Ordovas; Inga Peter; Wendy Post; Susan Redline; Steven E Reis; Richa Saxena; Pamela J Schreiner; Kelly A Volcik; Xingbin Wang; Salim Yusuf; Alan B Zonderland; Sonia S Anand; Diane M Becker; Bruce Psaty; Daniel J Rader; Alex P Reiner; Stephen S Rich; Jerome I Rotter; Michèle M Sale; Michael Y Tsai; Ingrid B Borecki; Robert A Hegele; Sekar Kathiresan; Michael A Nalls; Herman A Taylor; Hakon Hakonarson; Suthesh Sivapalaratnam; Folkert W Asselbergs; Fotios Drenos; James G Wilson; Brendan J Keating Journal: PLoS One Date: 2012-12-07 Impact factor: 3.240
Authors: Brian K Nordskog; Buddy G Brown; Kristin M Marano; Leanne R Campell; Bobbette A Jones; Michael F Borgerding Journal: Inhal Toxicol Date: 2015-03-19 Impact factor: 2.724