Literature DB >> 20005711

3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.

Robert R Singhaus1, Ronald C Bernotas, Robert Steffan, Edward Matelan, Elaine Quinet, Ponnal Nambi, Irene Feingold, Christine Huselton, Anna Wilhelmsson, Annika Goos-Nilsson, Jay Wrobel.   

Abstract

Replacement of a quinoline with an imidazo[1,2-a]pyridine in a series of liver X receptor (LXR) agonists incorporating a [3-(sulfonyl)aryloxyphenyl] side chain provided high affinity LXR ligands 7. In functional assays of LXR activity, good agonist potency and efficacy were found for several analogs. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 20005711     DOI： 10.1016/j.bmcl.2009.11.098

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Synthesis and biological activities of novel trifluoromethylpyridine amide derivatives containing sulfur moieties.

Authors:  S X Guo; F He; A L Dai; R F Zhang; S H Chen; J Wu
Journal:  RSC Adv       Date:  2020-09-28       Impact factor: 4.036

2.  Targeted Delivery of LXR Agonist Using a Site-Specific Antibody-Drug Conjugate.

Authors:  Reyna K V Lim; Shan Yu; Bo Cheng; Sijia Li; Nam-Jung Kim; Yu Cao; Victor Chi; Ji Young Kim; Arnab K Chatterjee; Peter G Schultz; Matthew S Tremblay; Stephanie A Kazane
Journal:  Bioconjug Chem       Date:  2015-05-20       Impact factor: 4.774

3.  Efficient access to 2,3-diarylimidazo[1,2-a]pyridines via a one-pot, ligand-free, palladium-catalyzed three-component reaction under microwave irradiation.

Authors:  Yuanxiang Wang; Brendan Frett; Hong-yu Li
Journal:  Org Lett       Date:  2014-05-22       Impact factor: 6.005
  3 in total

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