| Literature DB >> 20005104 |
Yingcai Wang1, Xianyun Jiao, Frank Kayser, Jiwen Liu, Zhongyu Wang, Malgorzata Wanska, Joanne Greenberg, Jennifer Weiszmann, Hongfei Ge, Hui Tian, Simon Wong, Ralf Schwandner, Taeweon Lee, Yang Li.
Abstract
Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor for which only short-chain fatty acids (SCFAs) have been reported as endogenous ligands. We describe the discovery and optimization of phenylacetamides as allosteric agonists of FFA2. These novel ligands can suppress adipocyte lipolysis in vitro and reduce plasma FFA levels in vivo, suggesting that these allosteric modulators can serve as pharmacological tools for exploring the potential function of FFA2 in various disease conditions. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 20005104 DOI： 10.1016/j.bmcl.2009.11.112
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823