OBJECTIVE: To assess the impact of adding exercise to dietary restriction on depressive symptoms and health-related quality of life (HRQOL) in women with polycystic ovary syndrome (PCOS). DESIGN: Analysis of depression and quality of life outcomes from a randomized, controlled prospective clinical intervention that evaluated the effects on a range of health outcomes in women with PCOS. SETTING: Clinical research unit. PATIENT(S): One hundred four overweight/obese PCOS women (aged 29.3 ± 0.7 years; body mass index [BMI] 36.1 ± 0.5 kg/m(2)). INTERVENTION(S): Randomized to one of three 20-week lifestyle programs: diet only, diet and aerobic exercise, or diet and combined aerobic-resistance exercise. MAIN OUTCOME MEASURE(S): Depression and PCOS-specific HRQOL. RESULT(S): Forty-nine women completed theintervention (diet only = 14, diet and aerobic exercise = 15, diet and combined aerobic-resistance exercise = 20). By week 20 all groups achieved weight loss and had improvements in depression and PCOS-specific HRQOL scores, except for body hair domain score. There was no difference between treatments for all outcomes. CONCLUSION(S): This study demonstrated that dietary restriction alone and combined with exercise had similar benefits for improving depression and HRQOL scores in overweight and obese women with PCOS.
RCT Entities:
OBJECTIVE: To assess the impact of adding exercise to dietary restriction on depressive symptoms and health-related quality of life (HRQOL) in women with polycystic ovary syndrome (PCOS). DESIGN: Analysis of depression and quality of life outcomes from a randomized, controlled prospective clinical intervention that evaluated the effects on a range of health outcomes in women with PCOS. SETTING: Clinical research unit. PATIENT(S): One hundred four overweight/obese PCOSwomen (aged 29.3 ± 0.7 years; body mass index [BMI] 36.1 ± 0.5 kg/m(2)). INTERVENTION(S): Randomized to one of three 20-week lifestyle programs: diet only, diet and aerobic exercise, or diet and combined aerobic-resistance exercise. MAIN OUTCOME MEASURE(S): Depression and PCOS-specific HRQOL. RESULT(S): Forty-nine women completed the intervention (diet only = 14, diet and aerobic exercise = 15, diet and combined aerobic-resistance exercise = 20). By week 20 all groups achieved weight loss and had improvements in depression and PCOS-specific HRQOL scores, except for body hair domain score. There was no difference between treatments for all outcomes. CONCLUSION(S): This study demonstrated that dietary restriction alone and combined with exercise had similar benefits for improving depression and HRQOL scores in overweight and obesewomen with PCOS.
Authors: Nigel K Stepto; Rhiannon K Patten; Eliza C Tassone; Marie L Misso; Leah Brennan; Jacqueline Boyle; Russell A Boyle; Cheryce L Harrison; Angelica Lindén Hirschberg; Kate Marsh; Alba Moreno-Asso; Leanne Redman; Mala Thondan; Chandrika Wijeyaratne; Helena J Teede; Lisa J Moran Journal: Sports Med Date: 2019-08 Impact factor: 11.136