Literature DB >> 20004261

A one-step method to fabricate PLLA scaffolds with deposition of bioactive hydroxyapatite and collagen using ice-based microporogens.

Jiashen Li1, Yun Chen, Arthur F T Mak, Rocky S Tuan, Lin Li, Yi Li.   

Abstract

Porous poly(l-lactic acid) (PLLA) scaffolds with bioactive coatings were prepared by a novel one-step method. In this process, ice-based microporogens containing bioactive molecules, such as hydroxyapatite (HA) and collagen, served as both porogens to form the porous structure and vehicles to transfer the bioactive molecules to the inside of PLLA scaffolds in a single step. Based on scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction and Fourier transform infrared spectroscopy analysis, the bioactive components were found to be transferred successfully from the porogens to PLLA scaffolds evenly. Osteoblast cells were used to evaluate the cellular behaviors of the composite scaffolds. After culturing for 8days, MTT assay and alkaline phosphatase activity results suggested that HA/collagen could improve the interactions between osteoblast cells and the polymeric scaffold. Copyright 2009 Acta Materialia Inc. All rights reserved.

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Year:  2009        PMID： 20004261      PMCID： PMC2862822          DOI： 10.1016/j.actbio.2009.12.008

Source DB:  PubMed          Journal:  Acta Biomater        ISSN： 1742-7061            Impact factor:   8.947


  30 in total

1.  Formation of bone-like apatite on poly(L-lactic acid) fibers by a biomimetic process.

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Journal:  J Biomed Mater Res       Date:  2001-10

2.  Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering.

Authors:  F Yang; R Murugan; S Ramakrishna; X Wang; Y-X Ma; S Wang
Journal:  Biomaterials       Date:  2004-05       Impact factor: 12.479

3.  Bone regeneration by recombinant human bone morphogenetic protein-2 and a novel biodegradable carrier in a rabbit ulnar defect model.

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Journal:  Biomaterials       Date:  2003-04       Impact factor: 12.479

4.  Formation of apatite on poly(alpha-hydroxy acid) in an accelerated biomimetic process.

Authors:  Yun Chen; Arthur F T Mak; Jiashen Li; Min Wang; Anita W T Shum
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2005-04       Impact factor: 3.368

5.  Poly(DL-lactic-co-glycolic acid) sponge hybridized with collagen microsponges and deposited apatite particulates.

Authors:  G Chen; T Ushida; T Tateishi
Journal:  J Biomed Mater Res       Date:  2001-10

6.  Hybrid coating of hydroxyapatite and collagen within poly(D,L-lactic-co-glycolic acid) scaffold.

Authors:  Jiashen Li; Xiaoyan Yuan; Fei He; Arthur F T Mak
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2008-08       Impact factor: 3.368

7.  Cartilage tissue engineering PLLA scaffold with surface immobilized collagen and basic fibroblast growth factor.

Authors:  Zuwei Ma; Changyou Gao; Yihong Gong; Jiacong Shen
Journal:  Biomaterials       Date:  2005-04       Impact factor: 12.479

8.  Fabrication of controlled release biodegradable foams by phase separation.

Authors:  H Lo; M S Ponticiello; K W Leong
Journal:  Tissue Eng       Date:  1995

9.  Bone formation on two-dimensional poly(DL-lactide-co-glycolide) (PLGA) films and three-dimensional PLGA tissue engineering scaffolds in vitro.

Authors:  Jeffrey M Karp; Molly S Shoichet; John E Davies
Journal:  J Biomed Mater Res A       Date:  2003-02-01       Impact factor: 4.396

10.  In vitro behavior of osteoblast-like cells on PLLA films with a biomimetic apatite or apatite/collagen composite coating.

Authors:  Y Chen; A F T Mak; M Wang; J S Li; M S Wong
Journal:  J Mater Sci Mater Med       Date:  2007-12-06       Impact factor: 3.896
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  9 in total

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2.  Effects of Inorganic Fillers on the Thermal and Mechanical Properties of Poly(lactic acid).

Authors:  Xingxun Liu; Tongxin Wang; Laurence C Chow; Mingshu Yang; James W Mitchell
Journal:  Int J Polym Sci       Date:  2014       Impact factor: 2.642

3.  Chitosan-coated pore wall polycaprolactone three-dimensional porous scaffolds fabricated by porogen leaching method for bone tissue engineering: a comparative study on blending technique to fabricate scaffolds.

Authors:  Deepak Poddar; Misba Majood; Ankita Singh; Sujata Mohanty; Purnima Jain
Journal:  Prog Biomater       Date:  2021-11-25

4.  Scaffold/Extracellular matrix hybrid constructs for bone-tissue engineering.

Authors:  Richard A Thibault; Antonios G Mikos; F Kurtis Kasper
Journal:  Adv Healthc Mater       Date:  2012-09-28       Impact factor: 9.933

5.  Biomimetic component coating on 3D scaffolds using high bioactivity of mesoporous bioactive ceramics.

Authors:  Hui-suk Yun; Sang-Hyun Kim; Dongwoo Khang; Jungil Choi; Hui-hoon Kim; Minji Kang
Journal:  Int J Nanomedicine       Date:  2011-10-21

6.  Morphological properties and proliferation analysis of olfactory ensheathing cells seeded onto three-dimensional collagen-heparan sulfate biological scaffolds.

Authors:  Na Liu; Zhouping Tang; Zhiyuan Yu; Minjie Xie; Yu Zhang; Erfang Yang; Shabei Xu
Journal:  Neural Regen Res       Date:  2012-06-05       Impact factor: 5.135

7.  An overview of polyester/hydroxyapatite composites for bone tissue repairing.

Authors:  Zeyu Fu; Jinjie Cui; Bin Zhao; Steve Gf Shen; Kaili Lin
Journal:  J Orthop Translat       Date:  2021-04-01       Impact factor: 5.191

Review 8.  Porous microsphere and its applications.

Authors:  Yunpeng Cai; Yinghui Chen; Xiaoyun Hong; Zhenguo Liu; Weien Yuan
Journal:  Int J Nanomedicine       Date:  2013-03-15

9.  One-Step Fabrication of Bone Morphogenetic Protein-2 Gene-Activated Porous Poly-L-Lactide Scaffold for Bone Induction.

Authors:  Jingwen Xue; Hang Lin; Allison Bean; Ying Tang; Jian Tan; Rocky S Tuan; Bing Wang
Journal:  Mol Ther Methods Clin Dev       Date:  2017-09-07       Impact factor: 6.698
  9 in total

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