Literature DB >> 20004044

Synthesis and antitumor activity of new dihydropyridine thioglycosides and their corresponding dehydrogenated forms.

Hebat-Allah S Abbas1, Wael A El Sayed, Nahed M Fathy.   

Abstract

A number of a new pyridine thioglycosides were synthesized via reaction of piperidinium salts of dihydropyridinethiones with 2,3,4,6-tetra-O-acetyl-alpha-D-gluco- and galactopyranosyl bromide. The antitumor activities of the synthesized compounds were evaluated utilizing two different human cell lines. Some of the tested compounds showed high inhibition of human cell lines. The detailed synthesis, spectroscopic data and antitumor activities for the synthesized compounds were reported. Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.

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Year:  2009        PMID： 20004044     DOI： 10.1016/j.ejmech.2009.11.039

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  12 in total

1.  Divergent synthesis of dual 1,4-dihydropyridines with different substituted patterns from enaminones and aldehydes through domino reactions.

Authors:  Fu-Jun Liu; Tian-Tian Sun; Yun-Gang Yang; Chao Huang; Xue-Bing Chen
Journal:  RSC Adv       Date:  2018-04-03       Impact factor: 3.361

2.  Assessment of the Cytotoxic Effect of a Series of 1,4-Dihydropyridine Derivatives Against Human Cancer Cells.

Authors:  Nima Razzaghi-Asl; Ramin Miri; Omidreza Firuzi
Journal:  Iran J Pharm Res       Date:  2016       Impact factor: 1.696

3.  Synthesis and Anticancer Activity of New 1-Thia-4-azaspiro[4.5]decane, Their Derived Thiazolopyrimidine and 1,3,4-Thiadiazole Thioglycosides.

Authors:  Eman M Flefel; Wael A El-Sayed; Ashraf M Mohamed; Walaa I El-Sofany; Hanem M Awad
Journal:  Molecules       Date:  2017-01-20       Impact factor: 4.411

4.  Synthesis and Cytotoxic Effect of Some Novel 1,2-Dihydropyridin-3-carbonitrile and Nicotinonitrile Derivatives.

Authors:  Eman M Flefel; Hebat-Allah S Abbas; Randa E Abdel Mageid; Wafaa A Zaghary
Journal:  Molecules       Date:  2015-12-31       Impact factor: 4.411

Review 5.  2-Amino-3,5-dicarbonitrile-6-sulfanylpyridines: synthesis and multiple biological activity - a review.

Authors:  Nail S Akhmadiev; Vnira R Akhmetova; Askhat G Ibragimov
Journal:  RSC Adv       Date:  2021-03-23       Impact factor: 3.361

Review 6.  Recent developments in the nanomaterial-catalyzed green synthesis of structurally diverse 1,4-dihydropyridines.

Authors:  Ritu Mathur; Khushal Singh Negi; Rahul Shrivastava; Rashmy Nair
Journal:  RSC Adv       Date:  2021-01-05       Impact factor: 3.361

7.  Novel 1,2,3-Triazole-Coumarin Hybrid Glycosides and Their Tetrazolyl Analogues: Design, Anticancer Evaluation and Molecular Docking Targeting EGFR, VEGFR-2 and CDK-2.

Authors:  Wael A El-Sayed; Fahad M Alminderej; Marwa M Mounier; Eman S Nossier; Sayed M Saleh; Asmaa F Kassem
Journal:  Molecules       Date:  2022-03-22       Impact factor: 4.411

8.  Microwave irradiation: a green approach for the synthesis of functionalized N-methyl-1,4-dihydropyridines.

Authors:  M Musawwer Khan; Sarfaraz Khan; Sumbulunnisan Shareef; Subash C Sahoo
Journal:  RSC Adv       Date:  2018-12-14       Impact factor: 4.036

9.  Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells.

Authors:  Siddarth Agrawal; Marta Wozniak; Mateusz Luc; Kinga Walaszek; Ewa Pielka; Wieslaw Szeja; Gabriela Pastuch-Gawolek; Andrzej Gamian; Piotr Ziolkowski
Journal:  Oncotarget       Date:  2017-12-11

10.  Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity.

Authors:  Adel A-H Abdel-Rahman; Amira K F Shaban; Ibrahim F Nassar; Dina S El-Kady; Nasser S M Ismail; Samy F Mahmoud; Hanem M Awad; Wael A El-Sayed
Journal:  Molecules       Date:  2021-06-26       Impact factor: 4.411
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