Literature DB >> 2000259

Hepatitis B virus mutants with precore-region defects in two babies with fulminant hepatitis and their mothers positive for antibody to hepatitis B e antigen.

S Terazawa1, M Kojima, T Yamanaka, S Yotsumoto, H Okamoto, F Tsuda, Y Miyakawa, M Mayumi.   

Abstract

Clones of hepatitis B virus (HBV) DNA were propagated from sera of two babies who developed neonatal fulminant hepatitis B, as well as from sera of their mothers who carried HBV with antibody to hepatitis B e antigen, and the precore-region sequences were determined. A point mutation from guanine to adenine, converting codon 28 for tryptophan (TGG) to a stop codon (TAG), was detected in 18 of 20 HBV DNA clones from mother and all 31 clones from baby in one family, and invariably in 55 clones from mother and three clones from baby in the other family. These results indicate that HBV mutants defective in the precore region in some carrier mothers with antibody to hepatitis B e antigen may transmit fulminant hepatitis B to their babies.

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Year:  1991        PMID： 2000259     DOI： 10.1203/00006450-199101000-00002

Source DB:  PubMed          Journal:  Pediatr Res        ISSN： 0031-3998            Impact factor:   3.756


  22 in total

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Review 4.  Viral hepatitis.

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5.  The serology of chronic hepatitis B infection revisited.

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6.  Cellular immunity in children with successful immunoprophylactic treatment for mother-to-child transmission of hepatitis B virus.

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7.  Assessment of differences in the conformational flexibility of hepatitis B virus core-antigen and e-antigen by hydrogen deuterium exchange-mass spectrometry.

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8.  Low level virus replication in infants with vertically transmitted fulminant hepatitis and their anti-HBe positive mothers.

Authors:  E Schaefer; H Koeppen; S Wirth
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9.  Distribution of hepatitis B viral genotypes and mutations in the core promoter and precore regions in acute forms of liver disease in patients from Chiba, Japan.

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10.  A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen.

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