AIMS: Neutrophil gelatinase-associated lipocalin (NGAL) is highly expressed in damaged epithelia, during inflammation and cardiovascular disease. Soluble NGAL was measured in women who subsequently developed gestational diabetes. METHODS: From a cohort of 908 pregnant outpatients who participated in a screening programme for Down's syndrome at 9-12 weeks of gestation, we considered all 41 women with a singleton pregnancy, who developed gestational diabetes in the previous 12 months, and a control group of 82 normal pregnancies. Circulating NGAL and insulin resistance by homeostasis model assessment ratio (HOMA-IR) were determined in the first trimester. RESULTS: Median serum NGAL concentrations were higher in the gestational diabetes group [51.3 ng/ml (39.8-66.1 ng/ml)] compared with the control group [17.8 ng/ml (15.5-20.9 ng/ml)] (P < 0.001) and positively correlated with HOMA-IR (P < 0.001). CONCLUSIONS: In the first trimester, circulating NGAL was significantly increased in women who subsequently developed gestational diabetes compared with the control group.
AIMS: Neutrophil gelatinase-associated lipocalin (NGAL) is highly expressed in damaged epithelia, during inflammation and cardiovascular disease. Soluble NGAL was measured in women who subsequently developed gestational diabetes. METHODS: From a cohort of 908 pregnant outpatients who participated in a screening programme for Down's syndrome at 9-12 weeks of gestation, we considered all 41 women with a singleton pregnancy, who developed gestational diabetes in the previous 12 months, and a control group of 82 normal pregnancies. Circulating NGAL and insulin resistance by homeostasis model assessment ratio (HOMA-IR) were determined in the first trimester. RESULTS: Median serum NGAL concentrations were higher in the gestational diabetes group [51.3 ng/ml (39.8-66.1 ng/ml)] compared with the control group [17.8 ng/ml (15.5-20.9 ng/ml)] (P < 0.001) and positively correlated with HOMA-IR (P < 0.001). CONCLUSIONS: In the first trimester, circulating NGAL was significantly increased in women who subsequently developed gestational diabetes compared with the control group.
Authors: Tina Ravnsborg; Lise Lotte T Andersen; Natacha D Trabjerg; Lars M Rasmussen; Dorte M Jensen; Martin Overgaard Journal: Diabetologia Date: 2016-01-27 Impact factor: 10.122
Authors: Elsa De La Chesnaye; Leticia Manuel-Apolinar; Leticia Damasio; Edgar Castrejón; Rebeca López-Ballesteros; María Cristina Revilla-Monsalve; Juan Pablo Méndez Journal: Mol Med Rep Date: 2020-06-12 Impact factor: 2.952
Authors: Mohammed Ghouse Ahmed Ansari; Syed Danish Hussain; Kaiser Ahmed Wani; Sobhy M Yakout; Dara Al-Disi; Majed S Alokail; Jean-Yves Reginster; Nasser M Al-Daghri Journal: Saudi J Biol Sci Date: 2019-10-31 Impact factor: 4.219