| Literature DB >> 20001906 |
Qing-Shan Fu1, Ai-Xin Song, Su-Xia Li, Hong-Yu Hu.
Abstract
Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinson's disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinson's disease-associated mutants do not appear to have reduced GTP hydrolysis activities.Entities:
Mesh：
Substances：
Year: 2009 PMID： 20001906 DOI： 10.2174/092986609789839386
Source DB: PubMed Journal: Protein Pept Lett ISSN： 0929-8665 Impact factor: 1.890