AIMS: Protein kinase Cs (PKCs) play important roles in cell proliferation, differentiation, apoptosis, migration and tumorigenesis. In this report, we investigated the expression of PKCeta in human hepatocellular carcinoma (HCC) tissues and explored its role in the development of HCC. METHODS: We used real-time quantitative RT-PCR, mutation analysis, and immunohistochemical staining to analyse the expression of PKCeta in 50 pairs of human hepatocellular carcinoma (HCC) tissues. RESULTS: Expression of PKCeta was down-regulated in 82% of HCC tissues and the reduction of PKCeta was associated with poorer long-term survival of HCC patients. CONCLUSION: Reduced expression of PKCeta may represent a molecular lesion in the development of more aggressive disease of HCC.
AIMS: Protein kinase Cs (PKCs) play important roles in cell proliferation, differentiation, apoptosis, migration and tumorigenesis. In this report, we investigated the expression of PKCeta in humanhepatocellular carcinoma (HCC) tissues and explored its role in the development of HCC. METHODS: We used real-time quantitative RT-PCR, mutation analysis, and immunohistochemical staining to analyse the expression of PKCeta in 50 pairs of humanhepatocellular carcinoma (HCC) tissues. RESULTS: Expression of PKCeta was down-regulated in 82% of HCC tissues and the reduction of PKCeta was associated with poorer long-term survival of HCC patients. CONCLUSION: Reduced expression of PKCeta may represent a molecular lesion in the development of more aggressive disease of HCC.
Authors: Corina E Antal; Andrew M Hudson; Emily Kang; Ciro Zanca; Christopher Wirth; Natalie L Stephenson; Eleanor W Trotter; Lisa L Gallegos; Crispin J Miller; Frank B Furnari; Tony Hunter; John Brognard; Alexandra C Newton Journal: Cell Date: 2015-01-22 Impact factor: 41.582
Authors: Jason K Cullen; Glen M Boyle; Pei-Yi Yap; Stefan Elmlinger; Jacinta L Simmons; Natasa Broit; Jenny Johns; Blake Ferguson; Lidia A Maslovskaya; Andrei I Savchenko; Paul Malek Mirzayans; Achim Porzelle; Paul V Bernhardt; Victoria A Gordon; Paul W Reddell; Alberto Pagani; Giovanni Appendino; Peter G Parsons; Craig M Williams Journal: Sci Rep Date: 2021-01-08 Impact factor: 4.379