PURPOSE: Ghrelin and its functional receptor are highly expressed in prostate cancer (PC) and ghrelin may activate proliferation of PC cell lines. This study was therefore designed to characterize the association between serum acylated and total ghrelin, and obestatin levels in patients with benign prostate hyperplasia (BPH) and PC. METHODS: Blood serum concentrations of active and total ghrelin and obestatin were estimated by EIA methods. RESULTS: Serum level of active ghrelin in PC was significantly higher compared to control and BPH groups. On the other hand, concentrations of total ghrelin and of obestatin did not differ between studied groups of patients. In the control group the ratio of active to total ghrelin concentrations amounted to 0.16, and it was similar in BPH (0.14), while it was notably elevated in PC (0.42). Also the ratio of active ghrelin to obestatin concentrations was higher in the group with PC than in the control and BPH groups. In all studied groups, the ratio of total circulating ghrelin to obestatin was similar. CONCLUSIONS: Obtained results suggest the link between elevated blood active ghrelin and PC, and we cannot exclude that elevated circulating active ghrelin may affect growth of malignant prostatic tissues. Copyright 2009 S. Karger AG, Basel.
PURPOSE:Ghrelin and its functional receptor are highly expressed in prostate cancer (PC) and ghrelin may activate proliferation of PC cell lines. This study was therefore designed to characterize the association between serum acylated and total ghrelin, and obestatin levels in patients with benign prostate hyperplasia (BPH) and PC. METHODS: Blood serum concentrations of active and total ghrelin and obestatin were estimated by EIA methods. RESULTS: Serum level of active ghrelin in PC was significantly higher compared to control and BPH groups. On the other hand, concentrations of total ghrelin and of obestatin did not differ between studied groups of patients. In the control group the ratio of active to total ghrelin concentrations amounted to 0.16, and it was similar in BPH (0.14), while it was notably elevated in PC (0.42). Also the ratio of active ghrelin to obestatin concentrations was higher in the group with PC than in the control and BPH groups. In all studied groups, the ratio of total circulating ghrelin to obestatin was similar. CONCLUSIONS: Obtained results suggest the link between elevated blood active ghrelin and PC, and we cannot exclude that elevated circulating active ghrelin may affect growth of malignant prostatic tissues. Copyright 2009 S. Karger AG, Basel.
Authors: Michelle L Maugham; Inge Seim; Patrick B Thomas; Gabrielle J Crisp; Esha T Shah; Adrian C Herington; Kristy A Brown; Laura S Gregory; Colleen C Nelson; Penny L Jeffery; Lisa K Chopin Journal: PLoS One Date: 2018-11-20 Impact factor: 3.240