Literature DB >> 19996293

Mutant metabolic enzymes are at the origin of gliomas.

Hai Yan1, Darell D Bigner, Victor Velculescu, D Williams Parsons.   

Abstract

Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors.

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Year:  2009        PMID： 19996293      PMCID： PMC2794981          DOI： 10.1158/0008-5472.CAN-09-2650

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   13.312


  22 in total

1.  Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children.

Authors:  James T Hayden; Michael C Frühwald; Martin Hasselblatt; David W Ellison; Simon Bailey; Steven C Clifford
Journal:  Cell Cycle       Date:  2009-06-30       Impact factor: 4.534

Review 2.  Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

Authors:  A King; M A Selak; E Gottlieb
Journal:  Oncogene       Date:  2006-08-07       Impact factor: 9.867

3.  The consensus coding sequences of human breast and colorectal cancers.

Authors:  Tobias Sjöblom; Siân Jones; Laura D Wood; D Williams Parsons; Jimmy Lin; Thomas D Barber; Diana Mandelker; Rebecca J Leary; Janine Ptak; Natalie Silliman; Steve Szabo; Phillip Buckhaults; Christopher Farrell; Paul Meeh; Sanford D Markowitz; Joseph Willis; Dawn Dawson; James K V Willson; Adi F Gazdar; James Hartigan; Leo Wu; Changsheng Liu; Giovanni Parmigiani; Ben Ho Park; Kurtis E Bachman; Nickolas Papadopoulos; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu
Journal:  Science       Date:  2006-09-07       Impact factor: 47.728

4.  Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers.

Authors:  Mi Ran Kang; Min Sung Kim; Ji Eun Oh; Yoo Ri Kim; Sang Yong Song; Seong Il Seo; Ji Youl Lee; Nam Jin Yoo; Sug Hyung Lee
Journal:  Int J Cancer       Date:  2009-07-15       Impact factor: 7.396

5.  Recurring mutations found by sequencing an acute myeloid leukemia genome.

Authors:  Elaine R Mardis; Li Ding; David J Dooling; David E Larson; Michael D McLellan; Ken Chen; Daniel C Koboldt; Robert S Fulton; Kim D Delehaunty; Sean D McGrath; Lucinda A Fulton; Devin P Locke; Vincent J Magrini; Rachel M Abbott; Tammi L Vickery; Jerry S Reed; Jody S Robinson; Todd Wylie; Scott M Smith; Lynn Carmichael; James M Eldred; Christopher C Harris; Jason Walker; Joshua B Peck; Feiyu Du; Adam F Dukes; Gabriel E Sanderson; Anthony M Brummett; Eric Clark; Joshua F McMichael; Rick J Meyer; Jonathan K Schindler; Craig S Pohl; John W Wallis; Xiaoqi Shi; Ling Lin; Heather Schmidt; Yuzhu Tang; Carrie Haipek; Madeline E Wiechert; Jolynda V Ivy; Joelle Kalicki; Glendoria Elliott; Rhonda E Ries; Jacqueline E Payton; Peter Westervelt; Michael H Tomasson; Mark A Watson; Jack Baty; Sharon Heath; William D Shannon; Rakesh Nagarajan; Daniel C Link; Matthew J Walter; Timothy A Graubert; John F DiPersio; Richard K Wilson; Timothy J Ley
Journal:  N Engl J Med       Date:  2009-08-05       Impact factor: 91.245

6.  An integrated genomic analysis of human glioblastoma multiforme.

Authors:  D Williams Parsons; Siân Jones; Xiaosong Zhang; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; I-Mei Siu; Gary L Gallia; Alessandro Olivi; Roger McLendon; B Ahmed Rasheed; Stephen Keir; Tatiana Nikolskaya; Yuri Nikolsky; Dana A Busam; Hanna Tekleab; Luis A Diaz; James Hartigan; Doug R Smith; Robert L Strausberg; Suely Kazue Nagahashi Marie; Sueli Mieko Oba Shinjo; Hai Yan; Gregory J Riggins; Darell D Bigner; Rachel Karchin; Nick Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
Journal:  Science       Date:  2008-09-04       Impact factor: 47.728

7.  Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

Authors:  Andrey Korshunov; Jochen Meyer; David Capper; Arne Christians; Marc Remke; Hendrik Witt; Stefan Pfister; Andreas von Deimling; Christian Hartmann
Journal:  Acta Neuropathol       Date:  2009-06-19       Impact factor: 17.088

8.  Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

Authors:  Christian Hartmann; Jochen Meyer; Jörg Balss; David Capper; Wolf Mueller; Arne Christians; Jörg Felsberg; Marietta Wolter; Christian Mawrin; Wolfgang Wick; Michael Weller; Christel Herold-Mende; Andreas Unterberg; Judith W M Jeuken; Peter Wesseling; Guido Reifenberger; Andreas von Deimling
Journal:  Acta Neuropathol       Date:  2009-06-25       Impact factor: 17.088

9.  IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.

Authors:  Koichi Ichimura; Danita M Pearson; Sylvia Kocialkowski; L Magnus Bäcklund; Raymond Chan; David T W Jones; V Peter Collins
Journal:  Neuro Oncol       Date:  2009-05-12       Impact factor: 12.300

10.  IDH1 and IDH2 mutations in gliomas.

Authors:  Hai Yan; D Williams Parsons; Genglin Jin; Roger McLendon; B Ahmed Rasheed; Weishi Yuan; Ivan Kos; Ines Batinic-Haberle; Siân Jones; Gregory J Riggins; Henry Friedman; Allan Friedman; David Reardon; James Herndon; Kenneth W Kinzler; Victor E Velculescu; Bert Vogelstein; Darell D Bigner
Journal:  N Engl J Med       Date:  2009-02-19       Impact factor: 176.079
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  70 in total

1.  IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group.

Authors:  Ian F Pollack; Ronald L Hamilton; Robert W Sobol; Marina N Nikiforova; Maureen A Lyons-Weiler; William A LaFramboise; Peter C Burger; Daniel J Brat; Marc K Rosenblum; Emiko J Holmes; Tianni Zhou; Regina I Jakacki
Journal:  Childs Nerv Syst       Date:  2010-08-20       Impact factor: 1.475

Review 2.  Genomic profiling of glioblastoma: convergence of fundamental biologic tenets and novel insights.

Authors:  Kimberly Ng; Ryan Kim; Santosh Kesari; Bob Carter; Clark C Chen
Journal:  J Neurooncol       Date:  2011-10-16       Impact factor: 4.130

3.  Re-evaluation of nondiagnostic biopsies of suspected low-grade glioma using isocitrate dehydrogenase 1 mutation immunohistochemistry.

Authors:  Mark D Anderson; Ty W Abel; Paul L Moots
Journal:  Neuro Oncol       Date:  2013-06-04       Impact factor: 12.300

4.  MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas.

Authors:  Ruth G Tatevossian; Bo Tang; James Dalton; Tim Forshew; Andrew R Lawson; Jing Ma; Geoff Neale; Sheila A Shurtleff; Simon Bailey; Amar Gajjar; Suzanne J Baker; Denise Sheer; David W Ellison
Journal:  Acta Neuropathol       Date:  2010-11-03       Impact factor: 17.088

5.  Malignant clinical features of anaplastic gliomas without IDH mutation.

Authors:  Ichiyo Shibahara; Yukihiko Sonoda; Takuhiro Shoji; Masayuki Kanamori; Ryuta Saito; Tomoo Inoue; Tomohiro Kawaguchi; Yoji Yamashita; Takashi Watanabe; Toshihiro Kumabe; Mika Watanabe; Hiroyoshi Suzuki; Teiji Tominaga
Journal:  Neuro Oncol       Date:  2014-06-23       Impact factor: 12.300

Review 6.  Medical therapy of gliomas.

Authors:  Manmeet S Ahluwalia; Susan M Chang
Journal:  J Neurooncol       Date:  2014-07-02       Impact factor: 4.130

Review 7.  Clinical implications of molecular neuropathology and biomarkers for malignant glioma.

Authors:  Ghazaleh Tabatabai; Monika Hegi; Roger Stupp; Michael Weller
Journal:  Curr Neurol Neurosci Rep       Date:  2012-06       Impact factor: 5.081

8.  Rare and uncommon genetic variants may hold key to the 'missing heritability' in glioma.

Authors:  Kathleen M Egan; Margaret R Wrensch; Robert B Jenkins
Journal:  CNS Oncol       Date:  2012-11

9.  Genome-wide methylation profiling identifies an essential role of reactive oxygen species in pediatric glioblastoma multiforme and validates a methylome specific for H3 histone family 3A with absence of G-CIMP/isocitrate dehydrogenase 1 mutation.

Authors:  Prerana Jha; Irene Rosita Pia Patric; Sudhanshu Shukla; Pankaj Pathak; Jagriti Pal; Vikas Sharma; Sivaarumugam Thinagararanjan; Vani Santosh; Vaishali Suri; Mehar Chand Sharma; Arimappamagan Arivazhagan; Ashish Suri; Deepak Gupta; Kumaravel Somasundaram; Chitra Sarkar
Journal:  Neuro Oncol       Date:  2014-07-04       Impact factor: 12.300

10.  Identification of a novel metabolic-related mutation (IDH1) in metastatic pancreatic cancer.

Authors:  Jonathan R Brody; Cinthya S Yabar; Mahsa Zarei; Joseph Bender; Lynn M Matrisian; Lola Rahib; Craig Heartwell; Kimberly Mason; Charles J Yeo; Stephen C Peiper; Wei Jiang; Katelyn Varieur; Subha Madhavan; Emanuel Petricoin; Danielle Fortuna; Mark Curtis; Zi-Xuan Wang; Michael J Pishvaian; Jordan M Winter
Journal:  Cancer Biol Ther       Date:  2018-03-06       Impact factor: 4.742
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