Literature DB >> 19996246

Treatment of resistant obsessive-compulsive disorder with ventral capsular/ventral striatal gamma capsulotomy: a pilot prospective study.

Antonio Carlos Lopes1, Benjamin D Greenberg, Georg Norén, Miguel Montes Canteras, Geraldo F Busatto, Maria Eugênia de Mathis, Anita Taub, Carina Chaubet D'Alcante, Marcelo Queiroz Hoexter, Fernando Sauerbronn Gouvea, Janaína Philippi Cecconi, André F Gentil, Ygor Arzeno Ferrão, Daniel Fuentes, Cláudio Campi de Castro, Cláudia C Leite, João Victor Salvajoli, Fábio L S Duran, Steven Rasmussen, Eurípedes Constantino Miguel.   

Abstract

A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects.

Entities:  

Mesh：

Year:  2009        PMID： 19996246     DOI： 10.1176/jnp.2009.21.4.381

Source DB:  PubMed          Journal:  J Neuropsychiatry Clin Neurosci        ISSN： 0895-0172            Impact factor:   2.198


  11 in total

1.  OCD behavior therapy before and after gamma ventral capsulotomy: case report.

Authors:  Christopher M Spofford; Nicole C R McLaughlin; Fred Penzel; Steven A Rasmussen; Benjamin D Greenberg
Journal:  Neurocase       Date:  2012-10-12       Impact factor: 0.881

2.  Bilateral thermal capsulotomy with MR-guided focused ultrasound for patients with treatment-refractory obsessive-compulsive disorder: a proof-of-concept study.

Authors:  H H Jung; S J Kim; D Roh; J G Chang; W S Chang; E J Kweon; C-H Kim; J W Chang
Journal:  Mol Psychiatry       Date:  2014-11-25       Impact factor: 15.992

3.  A study of novel bilateral thermal capsulotomy with focused ultrasound for treatment-refractory obsessive-compulsive disorder: 2-year follow-up.

Authors:  Se Joo Kim; Daeyoung Roh; Hyun Ho Jung; Won Seok Chang; Chan-Hyung Kim; Jin Woo Chang
Journal:  J Psychiatry Neurosci       Date:  2018-08       Impact factor: 6.186

4.  Differential assessment of frontally-mediated behaviors between self- and informant-report in patients with obsessive-compulsive disorder following gamma ventral capsulotomy.

Authors:  Michelle T Kassel; Olga Lositsky; Avinash R Vaidya; David Badre; Paul F Malloy; Benjamin D Greenberg; Richard Marsland; Georg Noren; Anna Sherman; Steven A Rasmussen; Nicole C R McLaughlin
Journal:  Neuropsychologia       Date:  2022-03-18       Impact factor: 3.054

5.  Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive-Compulsive Disorder Patients.

Authors:  Marcelo C Batistuzzo; Marcelo Q Hoexter; Anita Taub; André F Gentil; Raony C C Cesar; Marinês A Joaquim; Carina Chaubet D'Alcante; Nicole C McLaughlin; Miguel M Canteras; Roseli G Shavitt; Cary R Savage; Benjamin D Greenberg; Georg Norén; Eurípedes C Miguel; Antonio C Lopes
Journal:  Neuropsychopharmacology       Date:  2015-02-03       Impact factor: 7.853

Review 6.  Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders.

Authors:  Martin A Katzman; Pierre Bleau; Pierre Blier; Pratap Chokka; Kevin Kjernisted; Michael Van Ameringen; Martin M Antony; Stéphane Bouchard; Alain Brunet; Martine Flament; Sophie Grigoriadis; Sandra Mendlowitz; Kieron O'Connor; Kiran Rabheru; Peggy M A Richter; Melisa Robichaud; John R Walker
Journal:  BMC Psychiatry       Date:  2014-07-02       Impact factor: 3.630

Review 7.  Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD.

Authors:  Benjamin D Greenberg; Scott L Rauch; Suzanne N Haber
Journal:  Neuropsychopharmacology       Date:  2010-01       Impact factor: 7.853

8.  Electrical stimulation in the bed nucleus of the stria terminalis alleviates severe obsessive-compulsive disorder.

Authors:  L Luyten; S Hendrickx; S Raymaekers; L Gabriëls; B Nuttin
Journal:  Mol Psychiatry       Date:  2015-08-25       Impact factor: 15.992

9.  Understanding gamma ventral capsulotomy: Potential implications of diffusion tensor image tractography on target selectivity.

Authors:  Bruno Fernandes de Oliveira Santos; Alessandra Gorgulho; Crystian W C Saraiva; Antonio Carlos Lopes; João Gabriel Ribeiro Gomes; Anderson M Pássaro; Marcelo Q Hoexter; Eurípedes C Miguel; Antonio A F De Salles
Journal:  Surg Neurol Int       Date:  2019-07-05

10.  Evolution of gamma knife capsulotomy for intractable obsessive-compulsive disorder.

Authors:  Euripedes C Miguel; Antonio C Lopes; Nicole C R McLaughlin; Georg Norén; André F Gentil; Clement Hamani; Roseli G Shavitt; Marcelo C Batistuzzo; Edoardo F Q Vattimo; Miguel Canteras; Antonio De Salles; Alessandra Gorgulho; João Victor Salvajoli; Erich Talamoni Fonoff; Ian Paddick; Marcelo Q Hoexter; Christer Lindquist; Suzanne N Haber; Benjamin D Greenberg; Sameer A Sheth
Journal:  Mol Psychiatry       Date:  2018-05-09       Impact factor: 15.992
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