CONTEXT: Two sets of findings predict smaller cerebral cortical gray matter volume in adult posttraumatic stress disorder (PTSD). Measures of intracranial tissue volume and cerebral tissue volume have been observed to be smaller in adolescents with maltreatment-related PTSD. Second, lower intelligence, a risk factor for PTSD, is associated with smaller cerebral tissue volumes. Nevertheless, to our knowledge, only 1 study has observed globally smaller cerebral tissue volume in adults with PTSD. OBJECTIVES: To apply a recently developed method providing improved estimates of cortical volume and to estimate associations between adult PTSD and selected regional cortical volumes not yet investigated. DESIGN: Between-group comparison of global and regional cerebral cortical volumes in adult patients with combat-related PTSD and controls. SETTING: Two Department of Veterans Affairs medical centers with large inpatient and outpatient PTSD catchments. PARTICIPANTS: Ninety-seven combat-exposed veterans of the Vietnam and Persian Gulf wars. MAIN OUTCOME MEASURE: Global and regional cortical volumes determined using the FreeSurfer software program and the Desikan et al parcellation (modified). RESULTS: Cerebral cortical volume, thickness, and area were observed to be smaller in association with adult combat-related PTSD. Robust associations were observed between PTSD and smaller cortical volumes in the parahippocampal gyrus, superior temporal cortex, lateral orbital frontal cortex, and pars orbitalis of the inferior frontal gyrus. CONCLUSIONS: Cerebral cortical volume, thickness, and area may be smaller in adult chronic severe PTSD; however, the extracted structural variables did not mediate relations between intelligence and PTSD. The 4 regions exhibiting especially smaller cortical volumes in this sample share involvement in mechanisms subserving "top-down" facilitation of the identification of objects and words. Compromise of these regions may result in difficulty in relearning pretrauma schemata for interpreting the civilian physical and social environments.
CONTEXT: Two sets of findings predict smaller cerebral cortical gray matter volume in adult posttraumatic stress disorder (PTSD). Measures of intracranial tissue volume and cerebral tissue volume have been observed to be smaller in adolescents with maltreatment-related PTSD. Second, lower intelligence, a risk factor for PTSD, is associated with smaller cerebral tissue volumes. Nevertheless, to our knowledge, only 1 study has observed globally smaller cerebral tissue volume in adults with PTSD. OBJECTIVES: To apply a recently developed method providing improved estimates of cortical volume and to estimate associations between adult PTSD and selected regional cortical volumes not yet investigated. DESIGN: Between-group comparison of global and regional cerebral cortical volumes in adult patients with combat-related PTSD and controls. SETTING: Two Department of Veterans Affairs medical centers with large inpatient and outpatientPTSD catchments. PARTICIPANTS: Ninety-seven combat-exposed veterans of the Vietnam and Persian Gulf wars. MAIN OUTCOME MEASURE: Global and regional cortical volumes determined using the FreeSurfer software program and the Desikan et al parcellation (modified). RESULTS: Cerebral cortical volume, thickness, and area were observed to be smaller in association with adult combat-related PTSD. Robust associations were observed between PTSD and smaller cortical volumes in the parahippocampal gyrus, superior temporal cortex, lateral orbital frontal cortex, and pars orbitalis of the inferior frontal gyrus. CONCLUSIONS: Cerebral cortical volume, thickness, and area may be smaller in adult chronic severe PTSD; however, the extracted structural variables did not mediate relations between intelligence and PTSD. The 4 regions exhibiting especially smaller cortical volumes in this sample share involvement in mechanisms subserving "top-down" facilitation of the identification of objects and words. Compromise of these regions may result in difficulty in relearning pretrauma schemata for interpreting the civilian physical and social environments.
Authors: J Cobb Scott; Georg E Matt; Kristen M Wrocklage; Cassandra Crnich; Jessica Jordan; Steven M Southwick; John H Krystal; Brian C Schweinsburg Journal: Psychol Bull Date: 2014-11-03 Impact factor: 17.737
Authors: Valerie A Cardenas; Kristin Samuelson; Maryann Lenoci; Colin Studholme; Thomas C Neylan; Charles R Marmar; Norbert Schuff; Michael W Weiner Journal: Psychiatry Res Date: 2011-06-16 Impact factor: 3.222
Authors: Kristen M Wrocklage; Lynnette A Averill; J Cobb Scott; Christopher L Averill; Brian Schweinsburg; Marcia Trejo; Alicia Roy; Valerie Weisser; Christopher Kelly; Brenda Martini; Ilan Harpaz-Rotem; Steven M Southwick; John H Krystal; Chadi G Abdallah Journal: Eur Neuropsychopharmacol Date: 2017-03-06 Impact factor: 4.600
Authors: Amy E Ramage; Brett T Litz; Patricia A Resick; Mary D Woolsey; Katherine A Dondanville; Stacey Young-McCaughan; Adam M Borah; Elisa V Borah; Alan L Peterson; Peter T Fox Journal: Soc Cogn Affect Neurosci Date: 2015-09-15 Impact factor: 3.436
Authors: Gregory A Fonzo; Taru M Flagan; Sarah Sullivan; Carolyn B Allard; Erin M Grimes; Alan N Simmons; Martin P Paulus; Murray B Stein Journal: Psychiatry Res Date: 2012-11-13 Impact factor: 3.222
Authors: G A Fonzo; H J Ramsawh; T M Flagan; A N Simmons; S G Sullivan; C B Allard; M P Paulus; M B Stein Journal: Psychol Med Date: 2015-12-16 Impact factor: 7.723