OBJECTIVE: Youth who experience interpersonal trauma and have posttraumatic stress symptoms (PTSS) develop cognitive deficits that impact their development. Our goal is to investigate the function of the hippocampus in adolescents with PTSS during a memory processing task. METHODS: Twenty-seven adolescents between the ages of 10-17 years (16 with PTSS and 11 healthy controls) encoded and retrieved visually presented nouns (Verbal Declarative Memory Task) while undergoing fMRI scanning. RESULTS: The PTSS group demonstrated reduced activation of the right hippocampus during the retrieval component of the task. Further, severity of symptoms of avoidance and numbing correlated with reduced left hippocampal activation during retrieval. CONCLUSIONS: Decreased activity of the hippocampus during a verbal memory task may be a neurofunctional marker of PTSS in youth with history of interpersonal trauma. The results of this study may facilitate the development of focused treatments and may be of utility when assessing treatment outcome for PTSS.
OBJECTIVE: Youth who experience interpersonal trauma and have posttraumatic stress symptoms (PTSS) develop cognitive deficits that impact their development. Our goal is to investigate the function of the hippocampus in adolescents with PTSS during a memory processing task. METHODS: Twenty-seven adolescents between the ages of 10-17 years (16 with PTSS and 11 healthy controls) encoded and retrieved visually presented nouns (Verbal Declarative Memory Task) while undergoing fMRI scanning. RESULTS: The PTSS group demonstrated reduced activation of the right hippocampus during the retrieval component of the task. Further, severity of symptoms of avoidance and numbing correlated with reduced left hippocampal activation during retrieval. CONCLUSIONS: Decreased activity of the hippocampus during a verbal memory task may be a neurofunctional marker of PTSS in youth with history of interpersonal trauma. The results of this study may facilitate the development of focused treatments and may be of utility when assessing treatment outcome for PTSS.
Authors: N J King; B J Tonge; P Mullen; N Myerson; D Heyne; S Rollings; R Martin; T H Ollendick Journal: J Am Acad Child Adolesc Psychiatry Date: 2000-11 Impact factor: 8.829
Authors: Natalie S Werner; Thomas Meindl; Rolf R Engel; Rita Rosner; Michael Riedel; Maximilian Reiser; Kristina Fast Journal: J Psychiatr Res Date: 2008-05-19 Impact factor: 4.791
Authors: Tatiana Falcone; Damir Janigro; Rachel Lovell; Barry Simon; Charles A Brown; Mariela Herrera; Aye Mu Myint; Amit Anand Journal: J Psychiatr Res Date: 2014-12-25 Impact factor: 4.791
Authors: Hideo Suzuki; Joan L Luby; Kelly N Botteron; Rachel Dietrich; Mark P McAvoy; Deanna M Barch Journal: J Am Acad Child Adolesc Psychiatry Date: 2014-05-10 Impact factor: 8.829
Authors: Shefali Miller; Lisa M McTeague; Anett Gyurak; Brian Patenaude; Leanne M Williams; Stuart M Grieve; Mayuresh S Korgaonkar; Amit Etkin Journal: Depress Anxiety Date: 2015-04-27 Impact factor: 6.505
Authors: Ryan J Herringa; Rasmus M Birn; Paula L Ruttle; Cory A Burghy; Diane E Stodola; Richard J Davidson; Marilyn J Essex Journal: Proc Natl Acad Sci U S A Date: 2013-11-04 Impact factor: 11.205