Literature DB >> 19995561

Mitochondria-targeted antioxidant SkQR1 selectively protects MDR (Pgp 170)-negative cells against oxidative stress.

Elena K Fetisova1, Armine V Avetisyan, Denis S Izyumov, Mariya V Korotetskaya, Boris V Chernyak, Vladimir P Skulachev.   

Abstract

A conjugate of plastoquinone with decylrhodamine 19 (SkQR1) selectively accumulates in mitochondria of normal and tumor cells. SkQR1 protected the cellular pool of reduced glutathione under oxidative stress. Overexpression of P-glycoprotein (Pgp 170) multidrug resistance pump strongly suppresses accumulation of SkQR1. The inhibitors of Pgp 170 stimulate accumulation of SkQR1 in various cell lines indicating that SkQR1 is a substrate of Pgp 170. The protective effect of SkQR1 against oxidative stress is diminished in the cells overexpressing Pgp 170. It is suggested that mitochondria-targeted antioxidants could selectively protect normal (Pgp 170-negative) cells against the toxic effect of anti-cancer treatments related to oxidative stress. 2009. Published by Elsevier B.V.

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Year:  2009        PMID： 19995561     DOI： 10.1016/j.febslet.2009.12.002

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

1.  Multiple triphenylphosphonium cations as a platform for the delivery of a pro-apoptotic peptide.

Authors:  Netanel Kolevzon; Uriel Kuflik; Miriam Shmuel; Sandrine Benhamron; Israel Ringel; Eylon Yavin
Journal:  Pharm Res       Date:  2011-06-02       Impact factor: 4.200

2.  Effect of liposomes on energy-dependent uptake of the antioxidant SkQR1 by isolated mitochondria.

Authors:  Yuri N Antonenko; Irina V Perevoshchikova; Tatyana I Rokitskaya; Ruben A Simonyan; Vadim V Tashlitsky; Vladimir P Skulachev
Journal:  J Bioenerg Biomembr       Date:  2012-06-22       Impact factor: 2.945

3.  Novel mitochondria-targeted antioxidants: plastoquinone conjugated with cationic plant alkaloids berberine and palmatine.

Authors:  Konstantin G Lyamzaev; Antonina V Pustovidko; Ruben A Simonyan; Tatyana I Rokitskaya; Lidia V Domnina; Olga Yu Ivanova; Inna I Severina; Natalia V Sumbatyan; Galina A Korshunova; Vadim N Tashlitsky; Vitaly A Roginsky; Yuriy N Antonenko; Maxim V Skulachev; Boris V Chernyak; Vladimir P Skulachev
Journal:  Pharm Res       Date:  2011-06-14       Impact factor: 4.200

4.  Mitochondrial expression and activity of P-glycoprotein under oxidative stress in outer blood-retinal barrier.

Authors:  Yue-Hong Zhang; Juan Li; Wei-Zhong Yang; Zhuan-Hua Xian; Qi-Ting Feng; Xiang-Cai Ruan
Journal:  Int J Ophthalmol       Date:  2017-07-18       Impact factor: 1.779

Review 5.  Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications.

Authors:  Nadezda Apostolova; Victor M Victor
Journal:  Antioxid Redox Signal       Date:  2015-03-10       Impact factor: 8.401

6.  Effect of 7, 8-dihydroxyflavone on the up-regulation of Nrf2-mediated heme oxygenase-1 expression in hamster lung fibroblasts.

Authors:  Min Ju Ryu; Kyoung Ah Kang; Mei Jing Piao; Ki Cheon Kim; Jian Zheng; Cheng Wen Yao; Ji Won Cha; Chang Lim Hyun; Ha Sook Chung; Jong Cook Park; Suk Ju Cho; Jin Won Hyun
Journal:  In Vitro Cell Dev Biol Anim       Date:  2014-03-08       Impact factor: 2.416

7.  Derivatives of rhodamine 19 as mild mitochondria-targeted cationic uncouplers.

Authors:  Yuri N Antonenko; Armine V Avetisyan; Dmitry A Cherepanov; Dmitry A Knorre; Galina A Korshunova; Olga V Markova; Silvia M Ojovan; Irina V Perevoshchikova; Antonina V Pustovidko; Tatyana I Rokitskaya; Inna I Severina; Ruben A Simonyan; Ekaterina A Smirnova; Alexander A Sobko; Natalia V Sumbatyan; Fedor F Severin; Vladimir P Skulachev
Journal:  J Biol Chem       Date:  2011-03-30       Impact factor: 5.157

Review 8.  Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.

Authors:  Jacek Zielonka; Joy Joseph; Adam Sikora; Micael Hardy; Olivier Ouari; Jeannette Vasquez-Vivar; Gang Cheng; Marcos Lopez; Balaraman Kalyanaraman
Journal:  Chem Rev       Date:  2017-06-27       Impact factor: 60.622

9.  Induction of autophagy by depolarization of mitochondria.

Authors:  Konstantin G Lyamzaev; Artem V Tokarchuk; Alisa A Panteleeva; Armen Y Mulkidjanian; Vladimir P Skulachev; Boris V Chernyak
Journal:  Autophagy       Date:  2018-03-13       Impact factor: 16.016

10.  Penetrating cations enhance uncoupling activity of anionic protonophores in mitochondria.

Authors:  Yuri N Antonenko; Ljudmila S Khailova; Dmitry A Knorre; Olga V Markova; Tatyana I Rokitskaya; Tatyana M Ilyasova; Inna I Severina; Elena A Kotova; Yulia E Karavaeva; Anastasia S Prikhodko; Fedor F Severin; Vladimir P Skulachev
Journal:  PLoS One       Date:  2013-04-23       Impact factor: 3.240
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