Literature DB >> 1999273

Effects of IP3, spermine, and Mg2+ on regulation of Ca2+ transport by endoplasmic reticulum and mitochondria in permeabilized pancreatic islets.

S Lenzen1, I Rustenbeck.   

Abstract

Inositol 1,4,5-trisphosphate (IP3) increased the free-Ca2+ concentration in the incubation medium of permeabilized ob/ob mouse pancreatic islets. Spermine decreased the free-Ca2+ concentration through stimulation of mitochondrial Ca2+ uptake and attenuated the effect of IP3. Mg2+ antagonized the effects of spermine, thereby increasing the free-Ca2+ concentration and enhancing the effect of IP3 on the free-Ca2+ concentration. Because IP3 releases Ca2+ from endoplasmic reticulum, these results indicate that endoplasmic reticulum and mitochondria can interact in the regulation of the free-Ca2+ concentration in the cytosol of the pancreatic beta-cell.

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Year:  1991        PMID： 1999273     DOI： 10.2337/diab.40.3.323

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  7 in total

Review 1.  Slow voltage inactivation of Ca2+ currents and bursting mechanisms for the mouse pancreatic beta-cell.

Authors:  P Smolen; J Keizer
Journal:  J Membr Biol       Date:  1992-04       Impact factor: 1.843

2.  Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP3 Receptors in the Induction of Hyperalgesic Priming.

Authors:  Eugen V Khomula; Luiz F Ferrari; Dionéia Araldi; Jon D Levine
Journal:  J Neurosci       Date:  2017-01-23       Impact factor: 6.167

3.  Calcium accumulation by organelles within Myxicola axoplasm.

Authors:  N F al-Baldawi; J E Moore; R F Abercrombie
Journal:  J Physiol       Date:  1993-02       Impact factor: 5.182

4.  Dual effect of spermine on mitochondrial Ca2+ transport.

Authors:  S Lenzen; W Münster; I Rustenbeck
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

Review 5.  Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis.

Authors:  Abhishek Kulkarni; Cara M Anderson; Raghavendra G Mirmira; Sarah A Tersey
Journal:  Metabolites       Date:  2022-04-12

Review 6.  Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update.

Authors:  Raymond Vanholder; Anneleen Pletinck; Eva Schepers; Griet Glorieux
Journal:  Toxins (Basel)       Date:  2018-01-08       Impact factor: 4.546

Review 7.  Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes.

Authors:  Lorella Marselli; Emanuele Bosi; Carmela De Luca; Silvia Del Guerra; Marta Tesi; Mara Suleiman; Piero Marchetti
Journal:  Int J Mol Sci       Date:  2021-11-09       Impact factor: 5.923
  7 in total

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