Literature DB >> 1999227

A single-chain murine class I major transplantation antigen.

E Mottez1, C Jaulin, F Godeau, J Choppin, J P Levy, P Kourilsky.   

Abstract

Single-chain mouse Kd molecules (SC-Kd) were engineered by connecting residue 276 of Kd heavy chain to the first residue of beta 2-microglobulin through spacers of various lengths, and expressed intracellularly in monkey COS-1 cells. Labeled SC-Kd molecules were found to react with several monoclonal antibodies which recognize native Kd molecules. SC-Kd-15 (with a spacer of 15 residues) was studied in more details. It could be purified and shown to regain a native-like structure after treatment with denaturing agents. Purified SC-Kd-15 could bind certain peptides in a manner qualitatively similar to the Kd.

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Year:  1991        PMID： 1999227     DOI： 10.1002/eji.1830210232

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  8 in total

Review 1.  Properties and applications of single-chain major histocompatibility complex class I molecules.

Authors:  Eleni Kotsiou; Joanna Brzostek; Keith G Gould
Journal:  Antioxid Redox Signal       Date:  2011-03-31       Impact factor: 8.401

Review 2.  T cell antigen discovery.

Authors:  Alok V Joglekar; Guideng Li
Journal:  Nat Methods       Date:  2020-07-06       Impact factor: 28.547

3.  An efficient and versatile mammalian viral vector system for major histocompatibility complex class I/peptide complexes.

Authors:  Ai Kawana-Tachikawa; Mariko Tomizawa; Jun-Ichi Nunoya; Tatsuo Shioda; Atsushi Kato; Emi E Nakayama; Tetsuya Nakamura; Yoshiyuki Nagai; Aikichi Iwamoto
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

4.  Expression of a single-chain HLA class I molecule in a human cell line: presentation of exogenous peptide and processed antigen to cytotoxic T lymphocytes.

Authors:  K Toshitani; V Braud; M J Browning; N Murray; A J McMichael; W F Bodmer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205

5.  A recombinant, soluble, single-chain class I major histocompatibility complex molecule with biological activity.

Authors:  M G Mage; L Lee; R K Ribaudo; M Corr; S Kozlowski; L McHugh; D H Margulies
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

Review 6.  Antigen recognition and targeted delivery by the single-chain Fv.

Authors:  J S Huston; M S Tai; J McCartney; P Keck; H Oppermann
Journal:  Cell Biophys       Date:  1993 Jan-Jun

7.  Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness.

Authors:  J P Abastado; Y C Lone; A Casrouge; G Boulot; P Kourilsky
Journal:  J Exp Med       Date:  1995-08-01       Impact factor: 14.307

8.  Cells expressing a major histocompatibility complex class I molecule with a single covalently bound peptide are highly immunogenic.

Authors:  E Mottez; P Langlade-Demoyen; H Gournier; F Martinon; J Maryanski; P Kourilsky; J P Abastado
Journal:  J Exp Med       Date:  1995-02-01       Impact factor: 14.307
  8 in total

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