Literature DB >> 1997930

Cimetidine and coumarin therapy of renal cell carcinoma. A pilot study.

O Kokron1, S Maca, G Gasser, P R Schmidt.   

Abstract

Thirty-eight patients with metastatic renal-cell carcinoma (RCC) and 1 patient with a second primary RCC were treated with coumarin and cimetidine. Patients received 400 mg cimetidine p.o. daily and after 1 week 100 mg coumarin p.o. daily in addition until tumour progression. Two complete remission (30 and 50+ months) and 3 partial remissions (14, 13.8 months) could be achieved. Problems regarding possibly spontaneous regressions and comparable results of other treatment in RCC are discussed.

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Year:  1991        PMID： 1997930     DOI： 10.1159/000226905

Source DB:  PubMed          Journal:  Oncology        ISSN： 0030-2414            Impact factor:   2.935


  8 in total

Review 1.  Phytochemicals for the Prevention and Treatment of Renal Cell Carcinoma: Preclinical and Clinical Evidence and Molecular Mechanisms.

Authors:  Essa M Bajalia; Farah B Azzouz; Danielle A Chism; Derrek M Giansiracusa; Carina G Wong; Kristina N Plaskett; Anupam Bishayee
Journal:  Cancers (Basel)       Date:  2022-07-04       Impact factor: 6.575

2.  Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers.

Authors:  U Merkel; H Sigusch; A Hoffmann
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

3.  Suppression of the proliferation and migration of oncogenic ras-dependent cell lines, cultured in a three-dimensional collagen matrix, by flavonoid-structured molecules.

Authors:  H Q Lü; B Niggemann; K S Zänker
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

4.  Antitumour activity of coumarin and 7-hydroxycoumarin against 7,12-dimethylbenz[a]anthracene-induced rat mammary carcinomas.

Authors:  A Maucher; E von Angerer
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

5.  Growth-inhibitory effects of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin on human malignant cell lines in vitro.

Authors:  M E Marshall; K Kervin; C Benefield; A Umerani; S Albainy-Jenei; Q Zhao; M B Khazaeli
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

6.  The effects of coumarin and suramin on the growth of malignant renal and prostatic cell lines.

Authors:  R B Myers; M Parker; W E Grizzle
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

Review 7.  An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin.

Authors:  M E Marshall; J L Mohler; K Edmonds; B Williams; K Butler; M Ryles; L Weiss; D Urban; A Bueschen; M Markiewicz
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

Review 8.  Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms.

Authors:  Javad Sharifi-Rad; Natália Cruz-Martins; Pía López-Jornet; Eduardo Pons-Fuster Lopez; Nidaa Harun; Balakyz Yeskaliyeva; Ahmet Beyatli; Oksana Sytar; Shabnum Shaheen; Farukh Sharopov; Yasaman Taheri; Anca Oana Docea; Daniela Calina; William C Cho
Journal:  Oxid Med Cell Longev       Date:  2021-08-23       Impact factor: 6.543
  8 in total

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