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Literature DB >> 1997114

p53 in colorectal cancer: clinicopathological correlation and prognostic significance.

N Scott¹, P Sagar, J Stewart, G E Blair, M F Dixon, P Quirke.

Abstract

p53 protein was detected by immunohistochemistry in 42% of 52 colorectal adenocarcinomas. Positive tumours were significantly more frequent in the distal colon, and demonstrated a higher rate of cell proliferation. No correlation was found with tumour grade, Dukes' stage, presence of DNA aneuploidy or patient survival. The role of p53 in colorectal carcinogenesis is discussed with particular reference to differences between proximal and distal large bowel cancers.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1991 PMID： 1997114 PMCID： PMC1971769 DOI： 10.1038/bjc.1991.74

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

21 in total

1. T antigen is bound to a host protein in SV40-transformed cells.

Authors: D P Lane; L V Crawford
Journal: Nature Date: 1979-03-15 Impact factor: 49.962

2. The p53 proto-oncogene can act as a suppressor of transformation.

Authors: C A Finlay; P W Hinds; A J Levine
Journal: Cell Date: 1989-06-30 Impact factor: 41.582

3. SV40-53K antigen: a possible role for 53K in normal cells.

Authors: J Milner; S Milner
Journal: Virology Date: 1981-07-30 Impact factor: 3.616

4. Growth regulation of a cellular tumour antigen, p53, in nontransformed cells.

Authors: N C Reich; A J Levine
Journal: Nature Date: 1984 Mar 8-14 Impact factor: 49.962

5. Simultaneous monitoring of P53 protein and DNA content of colorectal adenocarcinomas by flow cytometry.

Authors: Y Remvikos; P Laurent-Puig; R J Salmon; G Frelat; B Dutrillaux; G Thomas
Journal: Int J Cancer Date: 1990-03-15 Impact factor: 7.396

6. Trends in right and left-sided colon cancer.

Authors: R W Beart; L J Melton; M Maruta; M B Dockerty; H B Frydenberg; W M O'Fallon
Journal: Dis Colon Rectum Date: 1983-06 Impact factor: 4.585

7. Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies.

Authors: W E Mercer; C Avignolo; R Baserga
Journal: Mol Cell Biol Date: 1984-02 Impact factor: 4.272

8. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas.

Authors: S J Baker; E R Fearon; J M Nigro; S R Hamilton; A C Preisinger; J M Jessup; P vanTuinen; D H Ledbetter; D F Barker; Y Nakamura; R White; B Vogelstein
Journal: Science Date: 1989-04-14 Impact factor: 47.728

9. Increased expression of mutant forms of p53 oncogene in primary lung cancer.

Authors: R Iggo; K Gatter; J Bartek; D Lane; A L Harris
Journal: Lancet Date: 1990-03-24 Impact factor: 79.321

10. Different age and sex relationship for cancer of subsites of the large bowel.

Authors: O M Jensen
Journal: Br J Cancer Date: 1984-12 Impact factor: 7.640

57 in total

Review 1. General surgery.

Authors: I Taylor
Journal: Postgrad Med J Date: 1991-10 Impact factor: 2.401

p53 in colorectal cancer: clinicopathological correlation and prognostic significance.

1. T antigen is bound to a host protein in SV40-transformed cells.

2. The p53 proto-oncogene can act as a suppressor of transformation.

3. SV40-53K antigen: a possible role for 53K in normal cells.

4. Growth regulation of a cellular tumour antigen, p53, in nontransformed cells.

5. Simultaneous monitoring of P53 protein and DNA content of colorectal adenocarcinomas by flow cytometry.

6. Trends in right and left-sided colon cancer.

7. Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies.

8. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas.

9. Increased expression of mutant forms of p53 oncogene in primary lung cancer.

10. Different age and sex relationship for cancer of subsites of the large bowel.

Review 1. General surgery.

Review 2. A systematic review of humoral immune responses against tumor antigens.

3. Loss of Bcl-2 expression correlates with tumour recurrence in colorectal cancer.

4. Prognostic significance of p53 expression in relation to DNA ploidy in colorectal adenocarcinoma.

5. Expression of p53 product in Chinese human bladder carcinoma.

6. p53 mutations in gastric and colorectal cancers in Texas Hispanics versus Anglos.

7. Overexpression of p53 protein in Barrett's syndrome with malignant transformation.

Review 8. Pathologic prognostic factors for gastrointestinal cancer.

9. Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations.

10. Physical deletion of the p53 gene in bladder cancer. Detection by fluorescence in situ hybridization.