Literature DB >> 19968590

In utero management of fetal lower urinary tract obstruction with a novel shunt: a landmark development in fetal therapy.

Ruben A Quintero1, Libardo Augusto Gomez Castro, Carlos Bermudez, Ramen H Chmait, Eftichia V Kontopoulos.   

Abstract

OBJECTIVE: Fetal lower urinary tract obstruction occurs in approximately 1:3000 pregnancies. Standard vesicoamniotic shunting is fraught with malfunctioning in upto 60% of cases. We hereby report the development and application of a novel and reliable shunt.
MATERIALS AND METHODS: Patients with lower urinary tract obstruction were offered the novel shunt among other standard management options. Shunting involved the placement of a double disk device with a standard double pig-tail catheter. All patients signed informed consent.
RESULTS: Four patients have been treated with the novel shunt. In three patients, shunting was conducted between the bladder and amniotic cavity. In one patient (dichorionic-discordant twins) with a prior dislodged shunt causing urinary ascites, shunting was conducted between the peritoneal and amniotic cavities ('bridge shunt'). In all cases, correct and stable shunt placement was confirmed endoscopically and sonographically and in all patients, the fetal bladder remains effectively drained.
CONCLUSION: Reliable and effective vesico or peritoneoamniotic shunting can be achieved with the novel shunt. This shunt cannot become dislodged into the peritoneal cavity or the amniotic cavity, and cannot be pulled out by the fetus. Further experience is necessary to determine the risks and benefits of this novel treatment for fetal lower urinary tract obstruction.

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Year:  2010        PMID: 19968590     DOI: 10.3109/14767050903443491

Source DB:  PubMed          Journal:  J Matern Fetal Neonatal Med        ISSN: 1476-4954


  4 in total

Review 1.  Fetal surgery: a critical review.

Authors:  H Kitagawa; K C Pringle
Journal:  Pediatr Surg Int       Date:  2017-01-05       Impact factor: 1.827

Review 2.  Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT).

Authors:  Maria M Rodriguez
Journal:  Fetal Pediatr Pathol       Date:  2014-10-14       Impact factor: 0.958

3.  Unusual fetal ascites and spontaneous bladder rupture in a female fetus: a case report.

Authors:  Florence Cadoret; Edith Brazet; Agnès Sartor; Isabelle Lacroix; Charlotte Casper; Stéphane Decramer; Olivier Parant
Journal:  J Med Case Rep       Date:  2020-07-19

4.  Advanced ultrasound for prenatal interventions.

Authors:  Katika Nawapun; Nisarat Phithakwatchara; Suparat Jaingam; Sommai Viboonchart; Nadda Mongkolchat; Tuangsit Wataganara
Journal:  Ultrasonography       Date:  2018-05-02
  4 in total

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