Literature DB >> 19967649

Transforming growth factor-beta as a treatment target in renal diseases.

Noboru Fukuda1, Yoshiko Tahira, Hiroyuki Matsuda, Koichi Matsumoto.   

Abstract

A number of studies have identified transforming growth factor-beta (TGF-beta) as a critical factor in renal diseases such as glomerulosclerosis and mesangioproliferative glomerulonephritis. TGF-beta stimulates proliferation of mesangial cells, production of extracellular matrix components and induces epithelial-mesenchymal transformation in renal tissue, which plays a critical role in the pathogenesis of renal injury. Thus, TGF-beta is a treatment target in renal diseases. However, progressive renal diseases cannot be cured with present medical technologies. We have developed ribozymes and a novel gene silencer pyrrole-imidazole polyamide targeted to TGF-beta that effectively ameliorate renal injury in hypertensive rats.

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Year:  2009        PMID： 19967649

Source DB:  PubMed          Journal:  J Nephrol        ISSN： 1121-8428            Impact factor:   3.902


  14 in total

1.  Transforming growth factor-β1 in children with diabetic nephropathy.

Authors:  Happy Sawires; Osama Botrous; Abdelmegeed Aboulmagd; Nadia Madani; Osama Abdelhaleem
Journal:  Pediatr Nephrol       Date:  2018-08-22       Impact factor: 3.714

2.  Purple corn anthocyanins retard diabetes-associated glomerulosclerosis in mesangial cells and db/db mice.

Authors:  Jing Li; Min-Kyung Kang; Jin-Kyu Kim; Jung-Lye Kim; Sang-Wook Kang; Soon Sung Lim; Young-Hee Kang
Journal:  Eur J Nutr       Date:  2011-11-20       Impact factor: 5.614

3.  RNA interference-directed caveolin-1 knockdown sensitizes SN12CPM6 cells to doxorubicin-induced apoptosis and reduces lung metastasis.

Authors:  Juwon Park; Eunkyung Bae; Chansu Lee; Sung-Soo Yoon; Yang Seok Chae; Kwang-Sung Ahn; Nam Hee Won
Journal:  Tumour Biol       Date:  2010-09-04

4.  Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension.

Authors:  David A Osmond; Shali Zhang; Jennifer S Pollock; Tatsuo Yamamoto; Carmen De Miguel; Edward W Inscho
Journal:  Am J Physiol Renal Physiol       Date:  2014-01-29

5.  Transforming Growth Factor-β1 as a Common Target Molecule for Development of Cardiovascular Diseases, Renal Insufficiency and Metabolic Syndrome.

Authors:  Ken-Ichi Aihara; Yasumasa Ikeda; Shusuke Yagi; Masashi Akaike; Toshio Matsumoto
Journal:  Cardiol Res Pract       Date:  2010-12-28       Impact factor: 1.866

Review 6.  Mechanisms and consequences of TGF-ß overexpression by podocytes in progressive podocyte disease.

Authors:  Hyun Soon Lee
Journal:  Cell Tissue Res       Date:  2011-05-04       Impact factor: 5.249

7.  Renoprotective action of a matrix metalloproteinase inhibitor in progressive mesangioproliferative nephritis.

Authors:  Takayuki Kuroda; Masao Masui; Mitsuru Notoya; Masashi Ito; Yoshinori Tamura; Hiroyuki Okamoto; Eri Kanaoka; Toshihiro Shinosaki
Journal:  Nephron Extra       Date:  2012-05-26

8.  Urinary Neutrophil Gelatinase-Associated Lipocalin to Monitor Lupus Nephritis Disease Activity.

Authors:  Hani Susianti; Jullyanny W Wijaya; Ati Rastini; Kusworini Handono; Atma Gunawan; Handono Kalim
Journal:  Biomark Insights       Date:  2015-09-06

9.  Calcium oxalate crystals and oxalate induce an epithelial-to-mesenchymal transition in the proximal tubular epithelial cells: Contribution to oxalate kidney injury.

Authors:  Marcia Bastos Convento; Edson Andrade Pessoa; Edgar Cruz; Maria Aparecida da Glória; Nestor Schor; Fernanda Teixeira Borges
Journal:  Sci Rep       Date:  2017-04-07       Impact factor: 4.379

10.  Chrysin Inhibits Advanced Glycation End Products-Induced Kidney Fibrosis in Renal Mesangial Cells and Diabetic Kidneys.

Authors:  Eun-Jung Lee; Min-Kyung Kang; Dong Yeon Kim; Yun-Ho Kim; Hyeongjoo Oh; Young-Hee Kang
Journal:  Nutrients       Date:  2018-07-09       Impact factor: 5.717
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