Literature DB >> 19967350

Examining the cardiac NK-2 genes in early heart development.

Heather Bartlett1, Gert Jan C Veenstra, Daniel L Weeks.   

Abstract

The cardiac NK-2 transcription factors are the vertebrate relatives of the Drosophila tinman gene. Without the Drosophila tinman gene, fruit flies fail to form their heart ("dorsal vessel"), and mutations or altered expression of cardiac NK-2 genes may lead to abnormal heart formation in vertebrates. Although the cardiac NK-2 gene NKX2-5 is recognized as an important factor in cases of human congenital heart disease and heart development in vertebrates, the roles of the other cardiac NK-2 genes are less clear. This report reviews what is known about the cardiac NK-2 genes in cardiac development, comparing studies in several different model systems.

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Year:  2009        PMID： 19967350      PMCID： PMC2981039          DOI： 10.1007/s00246-009-9605-0

Source DB:  PubMed          Journal:  Pediatr Cardiol        ISSN： 0172-0643            Impact factor:   1.655


  41 in total

Review 1.  Control of cardiac development by an evolutionarily conserved transcriptional network.

Authors:  Richard M Cripps; Eric N Olson
Journal:  Dev Biol       Date:  2002-06-01       Impact factor: 3.582

2.  Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation.

Authors:  Y Hiroi; S Kudoh; K Monzen; Y Ikeda; Y Yazaki; R Nagai; I Komuro
Journal:  Nat Genet       Date:  2001-07       Impact factor: 38.330

3.  Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease.

Authors:  H Kasahara; B Lee; J J Schott; D W Benson; J G Seidman; C E Seidman; S Izumo
Journal:  J Clin Invest       Date:  2000-07       Impact factor: 14.808

4.  Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx.

Authors:  M Tanaka; M Schinke; H S Liao; N Yamasaki; S Izumo
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

5.  Regulation of the tinman homologues in Xenopus embryos.

Authors:  D B Sparrow; C Cai; S Kotecha; B Latinkic; B Cooper; N Towers; S M Evans; T J Mohun
Journal:  Dev Biol       Date:  2000-11-01       Impact factor: 3.582

6.  Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site.

Authors:  Ching-Ling Lien; John McAnally; James A Richardson; Eric N Olson
Journal:  Dev Biol       Date:  2002-04-15       Impact factor: 3.582

7.  Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation.

Authors:  Petra E M H Habets; Antoon F M Moorman; Danielle E W Clout; Marian A van Roon; Merel Lingbeek; Maarten van Lohuizen; Marina Campione; Vincent M Christoffels
Journal:  Genes Dev       Date:  2002-05-15       Impact factor: 11.361

8.  The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer.

Authors:  Carl O Brown; Xuan Chi; Eduardo Garcia-Gras; Manabu Shirai; Xin-Hua Feng; Robert J Schwartz
Journal:  J Biol Chem       Date:  2003-12-08       Impact factor: 5.157

9.  GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation.

Authors:  Tessa Peterkin; Abigail Gibson; Roger Patient
Journal:  EMBO J       Date:  2003-08-15       Impact factor: 11.598

10.  Regulation of avian cardiogenesis by Fgf8 signaling.

Authors:  Burak H Alsan; Thomas M Schultheiss
Journal:  Development       Date:  2002-04       Impact factor: 6.868
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  16 in total

1.  Novel NKX2-5 mutations in patients with familial atrial septal defects.

Authors:  Xing-Yuan Liu; Juan Wang; Yi-Qing Yang; Yang-Yang Zhang; Xiao-Zhong Chen; Wei Zhang; Xiao-Zhou Wang; Jing-Hao Zheng; Yi-Han Chen
Journal:  Pediatr Cardiol       Date:  2010-12-25       Impact factor: 1.655

Review 2.  Sudden cardiac death and malignant arrhythmias: the scope of the problem in adult congenital heart patients.

Authors:  James C Perry
Journal:  Pediatr Cardiol       Date:  2012-02-09       Impact factor: 1.655

3.  Novel GATA6 mutations associated with congenital ventricular septal defect or tetralogy of fallot.

Authors:  Juan Wang; Xue-Jiao Luo; Yuan-Feng Xin; Yi Liu; Zhong-Min Liu; Qian Wang; Ruo-Gu Li; Wei-Yi Fang; Xiao-Zhou Wang; Yi-Qing Yang
Journal:  DNA Cell Biol       Date:  2012-09-28       Impact factor: 3.311

4.  MicroRNA expression, target genes, and signaling pathways in infants with a ventricular septal defect.

Authors:  Hui Chai; Zhaoyuan Yan; Ke Huang; Yuanqing Jiang; Lin Zhang
Journal:  Mol Cell Biochem       Date:  2017-08-18       Impact factor: 3.396

5.  A novel NKX2.6 mutation associated with congenital ventricular septal defect.

Authors:  Juan Wang; Jian-Hui Mao; Ke-Ke Ding; Wei-Jun Xu; Xing-Yuan Liu; Xing-Biao Qiu; Ruo-Gu Li; Xin-Kai Qu; Ying-Jia Xu; Ri-Tai Huang; Song Xue; Yi-Qing Yang
Journal:  Pediatr Cardiol       Date:  2014-11-08       Impact factor: 1.655

6.  Mutations of the GATA4 and NKX2.5 genes in Chinese pediatric patients with non-familial congenital heart disease.

Authors:  Ting Peng; Li Wang; Shu-Feng Zhou; Xiaotian Li
Journal:  Genetica       Date:  2010-11-26       Impact factor: 1.082

7.  A de novo mutation in NKX2.5 associated with atrial septal defects, ventricular noncompaction, syncope and sudden death.

Authors:  Ping Ouyang; Elizabeth Saarel; Ying Bai; Chunyan Luo; Qiulun Lv; Yan Xu; Fan Wang; Chun Fan; Adel Younoszai; Qiuyun Chen; Xin Tu; Qing K Wang
Journal:  Clin Chim Acta       Date:  2010-10-04       Impact factor: 3.786

8.  GATA5 loss-of-function mutation responsible for the congenital ventriculoseptal defect.

Authors:  Dong Wei; Han Bao; Ning Zhou; Gui-Fen Zheng; Xing-Yuan Liu; Yi-Qing Yang
Journal:  Pediatr Cardiol       Date:  2012-09-09       Impact factor: 1.655

9.  CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart.

Authors:  Yotam Blech-Hermoni; Connor B Sullivan; Michael W Jenkins; Oliver Wessely; Andrea N Ladd
Journal:  Dev Dyn       Date:  2016-05-31       Impact factor: 3.780

10.  Prevalence and spectrum of PITX2c mutations associated with congenital heart disease.

Authors:  Juan Wang; Yuan-Feng Xin; Wen-Jun Xu; Zhong-Min Liu; Xing-Biao Qiu; Xin-Kai Qu; Lei Xu; Xin Li; Yi-Qing Yang
Journal:  DNA Cell Biol       Date:  2013-10-01       Impact factor: 3.311
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