Literature DB >> 19966469

Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes.

Satoko Akiyama1, Shin-ichi Katsumata, Kazuharu Suzuki, Yumi Nakaya, Yoshiko Ishimi, Mariko Uehara.   

Abstract

We investigated the hypoglycemic and hypolipidemic effects of two hesperertin glycosides, namely, hesperidin and cyclodextrin (CD)-clathrated hesperetin, in Goto-Kakizaki (GK) weanling rats with type 2 diabetes. We demonstrated that hesperidin and CD-hesperetin normalized glucose metabolism by altering the activities of glucose-regulating enzymes and reducing the levels of lipids in the serum and liver of the GK rats. These effects of hesperidin glycosides were partly produced by altering the expression of genes encoding the peroxisome proliferator-activated receptors, 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, and the low-density lipoprotein receptor.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19966469     DOI： 10.1271/bbb.90576

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  30 in total

1.  Topical hesperidin prevents glucocorticoid-induced abnormalities in epidermal barrier function in murine skin.

Authors:  George Man; Theodora M Mauro; Peggy L Kim; Melanie Hupe; Yongjiao Zhai; Richard Sun; Debbie Crumrine; Carolyn Cheung; Almudena Nuno-Gonzalez; Peter M Elias; Mao-Qiang Man
Journal:  Exp Dermatol       Date:  2014-07-31       Impact factor: 3.960

2.  The effect of hesperidin supplementation on metabolic profiles in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial.

Authors:  Zahra Yari; Mina Movahedian; Hossein Imani; Seyed Moayed Alavian; Mehdi Hedayati; Azita Hekmatdoost
Journal:  Eur J Nutr       Date:  2019-12-16       Impact factor: 5.614

Review 3.  Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications.

Authors:  Kashif M Munir; Sruti Chandrasekaran; Feng Gao; Michael J Quon
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-07-30       Impact factor: 4.310

4.  Hesperidin prevents hyperglycemia in diabetic rats by activating the insulin receptor pathway.

Authors:  Peng Peng; Juan Jin; Guoliang Zou; Yanbo Sui; Yubo Han; Dapeng Zhao; Li Liu
Journal:  Exp Ther Med       Date:  2020-11-19       Impact factor: 2.447

5.  Flaxseed and/or hesperidin supplementation in metabolic syndrome: an open-labeled randomized controlled trial.

Authors:  Zahra Yari; Makan Cheraghpour; Azita Hekmatdoost
Journal:  Eur J Nutr       Date:  2020-04-15       Impact factor: 5.614

Review 6.  Mechanisms of body weight reduction and metabolic syndrome alleviation by tea.

Authors:  Chung S Yang; Jinsong Zhang; Le Zhang; Jinbao Huang; Yijun Wang
Journal:  Mol Nutr Food Res       Date:  2015-12-09       Impact factor: 5.914

Review 7.  Flavonoids as dietary regulators of nuclear receptor activity.

Authors:  Yishai Avior; David Bomze; Ory Ramon; Yaakov Nahmias
Journal:  Food Funct       Date:  2013-04-19       Impact factor: 5.396

8.  Bioflavonoid (Hesperidin) Restrains Protein Oxidation and Advanced Glycation End Product Formation by Targeting AGEs and Glycolytic Enzymes.

Authors:  Mohd Shahnawaz Khan; Md Tabish Rehman; Mohamed A Ismael; Mohamed F AlAjmi; Ghaida I Alruwaished; Majed S Alokail; Mohammad Rashid Khan
Journal:  Cell Biochem Biophys       Date:  2021-06-10       Impact factor: 2.194

9.  Protective role of biosynthesised zinc oxide nanoparticles on pancreatic beta cells: an in vitro and in vivo approach.

Authors:  Arul Daniel John; Ambalavanan Ragavee; Asha Devi Selvaraj
Journal:  IET Nanobiotechnol       Date:  2020-12       Impact factor: 1.847

10.  Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway.

Authors:  Xia Zhu; Yu-Meng Zhang; Meng-Ya Zhang; Ya-Jing Chen; Yao-Wu Liu
Journal:  Metab Brain Dis       Date:  2021-07-17       Impact factor: 3.584
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.