BACKGROUND: Although neuropathological observations suggest that cerebellar cortex is a major site of demyelination in multiple sclerosis (MS), only a few MRI studies on cerebellar cortical pathology in MS are available. OBJECTIVE: To analyse cerebellar cortical volume (CCV) and leucocortical lesions (CL) in MS, and their impact on clinical disability. METHODS: The authors studied 125 patients divided into 38 Clinical Isolated Syndrome (CIS), 35 relapsing remitting multiple sclerosis (RRMS), 27 secondary progressive multiple sclerosis (SPMS) and 25 primary progressive multiple sclerosis, and 32 normal controls (NC). CCV and cerebellar CL number and volume were evaluated by means of Freesurfer software and Double Inversion Recovery, respectively. RESULTS: Compared with NC (mean 113.2 + or - 2.6 cm(3)), the CCV was significantly reduced in CIS (105.4 + or - 2.2 cm(3), p=0.018), RRMS (104.0 + or - 2.0 cm(3), p=0.012), SPMS (98.8 + or - 2.0 cm(3), p<0.001) and PPMS (100.6 + or - 2.2 cm(3), p<0.001), even after age, gender and mean cortical volume correction. CL were observed in all patient groups and were an independent predictor of CCV and cerebellar dysfunction. DISCUSSION: The authors confirm that the cerebellar cortex is severely and early affected by MS pathology. The monitoring of cerebellar cortical atrophy and CL may help to understand the mechanism underlying disability progression in MS.
BACKGROUND: Although neuropathological observations suggest that cerebellar cortex is a major site of demyelination in multiple sclerosis (MS), only a few MRI studies on cerebellar cortical pathology in MS are available. OBJECTIVE: To analyse cerebellar cortical volume (CCV) and leucocortical lesions (CL) in MS, and their impact on clinical disability. METHODS: The authors studied 125 patients divided into 38 Clinical Isolated Syndrome (CIS), 35 relapsing remitting multiple sclerosis (RRMS), 27 secondary progressive multiple sclerosis (SPMS) and 25 primary progressive multiple sclerosis, and 32 normal controls (NC). CCV and cerebellar CL number and volume were evaluated by means of Freesurfer software and Double Inversion Recovery, respectively. RESULTS: Compared with NC (mean 113.2 + or - 2.6 cm(3)), the CCV was significantly reduced in CIS (105.4 + or - 2.2 cm(3), p=0.018), RRMS (104.0 + or - 2.0 cm(3), p=0.012), SPMS (98.8 + or - 2.0 cm(3), p<0.001) and PPMS (100.6 + or - 2.2 cm(3), p<0.001), even after age, gender and mean cortical volume correction. CL were observed in all patient groups and were an independent predictor of CCV and cerebellar dysfunction. DISCUSSION: The authors confirm that the cerebellar cortex is severely and early affected by MS pathology. The monitoring of cerebellar cortical atrophy and CL may help to understand the mechanism underlying disability progression in MS.
Authors: Valeria T Barletta; Elena Herranz; Costantina A Treaba; Russell Ouellette; Ambica Mehndiratta; Marco L Loggia; Eric C Klawiter; Carolina Ionete; Sloane A Jacob; Caterina Mainero Journal: Mult Scler Date: 2019-04-11 Impact factor: 6.312
Authors: Allan MacKenzie-Graham; Gilda A Rinek; Andrea Avedisian; Stefan M Gold; Andrew J Frew; Cynthia Aguilar; David R Lin; Elizabeth Umeda; Rhonda R Voskuhl; Jeffry R Alger Journal: Neuroimage Date: 2011-12-13 Impact factor: 6.556
Authors: Katrin Weier; Andreas Beck; Stefano Magon; Michael Amann; Yvonne Naegelin; Iris K Penner; Markus Thürling; Volker Aurich; Tobias Derfuss; Ernst-Wilhelm Radue; Christoph Stippich; Ludwig Kappos; Dagmar Timmann; Till Sprenger Journal: J Neurol Date: 2012-06-19 Impact factor: 4.849
Authors: Allan J MacKenzie-Graham; Gilda A Rinek; Andrea Avedisian; Laurie B Morales; Elizabeth Umeda; Benoit Boulat; Russell E Jacobs; Arthur W Toga; Rhonda R Voskuhl Journal: J Neurosci Res Date: 2012-03-13 Impact factor: 4.164
Authors: Katrin Weier; Brenda Banwell; Antonio Cerasa; D Louis Collins; Anne-Marie Dogonowski; Hans Lassmann; Aldo Quattrone; Mohammad A Sahraian; Hartwig R Siebner; Till Sprenger Journal: Cerebellum Date: 2015-06 Impact factor: 3.847
Authors: Myrte Strik; L Eduardo Cofré Lizama; Camille J Shanahan; Anneke van der Walt; Frederique M C Boonstra; Rebecca Glarin; Trevor J Kilpatrick; Jeroen J G Geurts; Jon O Cleary; Menno M Schoonheim; Mary P Galea; Scott C Kolbe Journal: Brain Commun Date: 2021-03-16