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Literature DB >> 19964958

Degradable polymers for gene delivery.

Joel Sunshine¹, Nupura Bhise, Jordan J Green.

Abstract

Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure led to significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than Lipofectamine 2000 or polyethylenimine for gene delivery to cancerous fibroblasts or human primary fibroblasts. These materials may be useful for cancer therapeutics and regenerative medicine.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19964958 PMCID： PMC3959118 DOI： 10.1109/IEMBS.2009.5334767

Source DB: PubMed Journal: Conf Proc IEEE Eng Med Biol Soc ISSN： 1557-170X

20 in total

1. Development of a novel gene delivery scaffold utilizing colloidal gold-polyethylenimine conjugates for DNA condensation.

Authors: M M Ow Sullivan; J J Green; T M Przybycien
Journal: Gene Ther Date: 2003-10 Impact factor: 5.250

3. Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells.

Authors: Nupura S Bhise; Karl J Wahlin; Donald J Zack; Jordan J Green
Journal: Int J Nanomedicine Date: 2013-12-04

3 in total

Degradable polymers for gene delivery.

1. Development of a novel gene delivery scaffold utilizing colloidal gold-polyethylenimine conjugates for DNA condensation.

2. Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters).

3. A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy.

Review 4. Design and development of polymers for gene delivery.

5. Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery.

6. A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery.

7. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery.

8. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes.

9. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

10. Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis.

Review 1. Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery.

2. 2011 Rita Schaffer lecture: nanoparticles for intracellular nucleic acid delivery.

3. Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells.