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Literature DB >> 19964708

Intraurethral activation of excitatory bladder reflexes in persons with spinal cord injury.

Paul B Yoo¹, Eric E Horvath, Cindy L Amundsen, George D Webster, Warren M Grill.

Abstract

Electrical activation of an excitatory reflex between sensory fibers in the pudendal nerve and the bladder has been demonstrated in cats and is a potential means of restoring micturition function in persons with spinal cord injury. We investigated the clinical feasibility of activating this reflex to restore bladder function in persons with spinal cord injury by using intraurethral electrical stimulation to activate pudendal sensory fibers innervating the urethra. Excitatory bladder responses (contractions) were evoked by trains of electrical pulses applied to either the proximal (29.7 +/- 11.6 cmH2O) or distal (30.2 +/- 11.6 cmH2O) segment of the urethra. The results indicate that an excitatory reflex between pudendal nerve afferents and the bladder exists in humans with spinal injury and may provide a substrate for restoring micturition function.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2009 PMID： 19964708 PMCID： PMC3662296 DOI： 10.1109/IEMBS.2009.5333982

Source DB: PubMed Journal: Conf Proc IEEE Eng Med Biol Soc ISSN： 1557-170X

15 in total

1. Spinal micturition reflex mediated by afferents in the deep perineal nerve.

Authors: Joseph W Boggs; Brian J Wenzel; Kenneth J Gustafson; Warren M Grill
Journal: J Neurophysiol Date: 2004-12-15 Impact factor: 2.714

2. Pudendal-to-bladder reflex in chronic spinal-cord-injured cats.

Authors: Changfeng Tai; Stanley E Smerin; William C de Groat; James R Roppolo
Journal: Exp Neurol Date: 2005-11-02 Impact factor: 5.330

3. Bladder activation by selective stimulation of pudendal nerve afferents in the cat.

Authors: Paul B Yoo; John P Woock; Warren M Grill
Journal: Exp Neurol Date: 2008-04-20 Impact factor: 5.330

4. Activation and inhibition of the micturition reflex by penile afferents in the cat.

Authors: John P Woock; Paul B Yoo; Warren M Grill
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2008-04-23 Impact factor: 3.619

5. Urethral pudendal afferent-evoked bladder and sphincter reflexes in decerebrate and acute spinal cats.

Authors: S J Shefchyk; R R Buss
Journal: Neurosci Lett Date: 1998-03-20 Impact factor: 3.046

6. Inhibiting the hyperreflexic bladder with electrical stimulation in a spinal animal model.

Authors: J S Walter; J S Wheeler; C J Robinson; R D Wurster
Journal: Neurourol Urodyn Date: 1993 Impact factor: 2.696

7. Minimally-invasive electrical stimulation of the pudendal nerve: a pre-clinical study for neural control of the lower urinary tract.

Authors: Paul B Yoo; Warren M Grill
Journal: Neurourol Urodyn Date: 2007 Impact factor: 2.696

Intraurethral activation of excitatory bladder reflexes in persons with spinal cord injury.

1. Spinal micturition reflex mediated by afferents in the deep perineal nerve.

2. Pudendal-to-bladder reflex in chronic spinal-cord-injured cats.

3. Bladder activation by selective stimulation of pudendal nerve afferents in the cat.

4. Activation and inhibition of the micturition reflex by penile afferents in the cat.

5. Urethral pudendal afferent-evoked bladder and sphincter reflexes in decerebrate and acute spinal cats.

6. Inhibiting the hyperreflexic bladder with electrical stimulation in a spinal animal model.

7. Minimally-invasive electrical stimulation of the pudendal nerve: a pre-clinical study for neural control of the lower urinary tract.

8. Treatment of neurogenic detrusor overactivity in spinal cord injured patients by conditional electrical stimulation.

9. A urethral afferent mediated excitatory bladder reflex exists in humans.

10. Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury.

1. Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E₂ rat model of overactive bladder.

2. Phasic activation of the external urethral sphincter increases voiding efficiency in the rat and the cat.

Review 3. Electrical stimulation for neuroregeneration in urology: a new therapeutic paradigm.

4. Impact of Bioelectronic Medicine on the Neural Regulation of Pelvic Visceral Function.