A new improved model-based seizure detection using statistically optimal null filter.

A patient-specific model-based seizure detection method using statistically optimal null filters (SONF) has been recently proposed to aid the review of long-term EEG [1, 2]. The method relies on the model of a priori known seizure (template pattern) for subsequent detection of similar seizures. Artifacts, non-epileptic EEG rhythms, and at times modeling errors lead to increased false or missed detections. In this paper, we present a new improved model-based seizure detection that introduces a pre-processing block for artifact rejection, an adaptive technique of modeling the template patterns, and a new evolution-based classifier. The proposed classifier tracks the temporal evolution of seizure to improve the classification accuracy. With the help of simulated EEG, we illustrate the significance and need for these modifications. Further, performance of the complete algorithm is tested on single channel depth EEG of seven patients, and compared with the previous approaches. In terms of sensitivity and specificity, the proposed method resulted in 84% and 100%, method of [1] 65% and 84%, and method of [2], 84% and 90% respectively. An overall performance improvement is seen as enhanced detection sensitivity and reduced false positives. This is preliminary result on seven patient data.