Literature DB >> 19963818

Multi-scale modeling of excitation-contraction coupling in the normal and failing heart.

Roy C P Kerckhoffs1, Stuart G Campbell, Sarah N Flaim, Elliot J Howard, Jazmin Sierra-Aguado, L J Mulligan, Andrew D McCulloch.   

Abstract

Here we describe new computational models of cardiac electromechanics starting from the cellular scale and building to the tissue, organ and system scales. We summarize application to human genetic diseases (LQT1 and LQT3) and to modeling of congestive heart failure.

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Year:  2009        PMID： 19963818      PMCID： PMC2896048          DOI： 10.1109/IEMBS.2009.5332708

Source DB:  PubMed          Journal:  Conf Proc IEEE Eng Med Biol Soc        ISSN： 1557-170X


  7 in total

1.  Arrhythmogenic consequences of Na+ channel mutations in the transmurally heterogeneous mammalian left ventricle: analysis of the I1768V SCN5A mutation.

Authors:  Sarah N Flaim; Wayne R Giles; Andrew D McCulloch
Journal:  Heart Rhythm       Date:  2007-02-20       Impact factor: 6.343

2.  Mechanical discoordination rather than dyssynchrony predicts reverse remodeling upon cardiac resynchronization.

Authors:  Borut Kirn; Annemieke Jansen; Frank Bracke; Berry van Gelder; Theo Arts; Frits W Prinzen
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-05-30       Impact factor: 4.733

3.  Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes.

Authors:  Sarah N Flaim; Wayne R Giles; Andrew D McCulloch
Journal:  Am J Physiol Heart Circ Physiol       Date:  2006-07-07       Impact factor: 4.733

4.  Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue.

Authors:  Jeffrey J Saucerman; Sarah N Healy; Mary E Belik; Jose L Puglisi; Andrew D McCulloch
Journal:  Circ Res       Date:  2004-11-04       Impact factor: 17.367

5.  Acetylcholine-induced shortening of the epicardial action potential duration may increase repolarization gradients and LQT3 arrhythmic risk.

Authors:  Sarah N Flaim; Andrew D McCulloch
Journal:  J Electrocardiol       Date:  2007 Nov-Dec       Impact factor: 1.438

6.  Effect of transmurally heterogeneous myocyte excitation-contraction coupling on canine left ventricular electromechanics.

Authors:  Stuart G Campbell; Elliot Howard; Jazmin Aguado-Sierra; Benjamin A Coppola; Jeffrey H Omens; Lawrence J Mulligan; Andrew D McCulloch; Roy C P Kerckhoffs
Journal:  Exp Physiol       Date:  2009-02-27       Impact factor: 2.969

7.  Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model.

Authors:  Stuart G Campbell; Sarah N Flaim; Chae H Leem; Andrew D McCulloch
Journal:  Philos Trans A Math Phys Eng Sci       Date:  2008-09-28       Impact factor: 4.226
  7 in total
  7 in total

1.  The direct incorporation of perfusion defect information to define ischemia and infarction in a finite element model of the left ventricle.

Authors:  Alexander I Veress; George S K Fung; Taek-Soo Lee; Benjamin M W Tsui; Gregory A Kicska; W Paul Segars; Grant T Gullberg
Journal:  J Biomech Eng       Date:  2015-02-25       Impact factor: 2.097

2.  Incorporation of a left ventricle finite element model defining infarction into the XCAT imaging phantom.

Authors:  Alexander I Veress; W Paul Segars; Benjamin M W Tsui; Grant T Gullberg
Journal:  IEEE Trans Med Imaging       Date:  2010-10-28       Impact factor: 10.048

3.  Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention.

Authors:  Yanhang Zhang; Victor H Barocas; Scott A Berceli; Colleen E Clancy; David M Eckmann; Marc Garbey; Ghassan S Kassab; Donna R Lochner; Andrew D McCulloch; Roger Tran-Son-Tay; Natalia A Trayanova
Journal:  Ann Biomed Eng       Date:  2016-05-02       Impact factor: 3.934

4.  Multiscale Computational Analysis of Right Ventricular Mechanoenergetics.

Authors:  Ryan J Pewowaruk; Jennifer L Philip; Shivendra G Tewari; Claire S Chen; Mark S Nyaeme; Zhijie Wang; Diana M Tabima; Anthony J Baker; Daniel A Beard; Naomi C Chesler
Journal:  J Biomech Eng       Date:  2018-08-01       Impact factor: 2.097

Review 5.  Three-dimensional cardiac computational modelling: methods, features and applications.

Authors:  Alejandro Lopez-Perez; Rafael Sebastian; Jose M Ferrero
Journal:  Biomed Eng Online       Date:  2015-04-17       Impact factor: 2.819

6.  Patient-Specific MRI-Based Right Ventricle Models Using Different Zero-Load Diastole and Systole Geometries for Better Cardiac Stress and Strain Calculations and Pulmonary Valve Replacement Surgical Outcome Predictions.

Authors:  Dalin Tang; Pedro J Del Nido; Chun Yang; Heng Zuo; Xueying Huang; Rahul H Rathod; Vasu Gooty; Alexander Tang; Zheyang Wu; Kristen L Billiar; Tal Geva
Journal:  PLoS One       Date:  2016-09-14       Impact factor: 3.240

7.  Impaired Myofilament Contraction Drives Right Ventricular Failure Secondary to Pressure Overload: Model Simulations, Experimental Validation, and Treatment Predictions.

Authors:  Jennifer L Philip; Ryan J Pewowaruk; Claire S Chen; Diana M Tabima; Daniel A Beard; Anthony J Baker; Naomi C Chesler
Journal:  Front Physiol       Date:  2018-06-27       Impact factor: 4.566
  7 in total

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