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Literature DB >> 1996341

Identification of the ancestral haplotype for apolipoprotein B suggests an African origin of Homo sapiens sapiens and traces their subsequent migration to Europe and the Pacific.

J Rapacz¹, L Chen, E Butler-Brunner, M J Wu, J O Hasler-Rapacz, R Butler, V N Schumaker.

Abstract

The probable ancestral haplotype for human apolipoprotein B (apoB) has been identified through immunological analysis of chimpanzee and gorilla serum and sequence analysis of their DNA. Moreover, the frequency of this ancestral apoB haplotype among different human populations provides strong support for the African origin of Homo sapiens sapiens and their subsequent migration from Africa to Europe and to the Pacific. The approach used here for the identification of the ancestral human apoB haplotype is likely to be applicable to many other genes.

Entities: Gene Species

Mesh：

Substances：
Apolipoproteins B

Year: 1991 PMID： 1996341 PMCID： PMC51026 DOI： 10.1073/pnas.88.4.1403

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

10 in total

1. Bsp 12861 restriction fragment length polymorphism detects Ag(c/g) locus of human apolipoprotein B in all 17 persons studied.

Authors: Y H Ma; X B Wang; R Bütler; V N Schumaker
Journal: Arteriosclerosis Date: 1989 Mar-Apr

2. DNA sequence of the human apolipoprotein B gene.

Authors: E H Ludwig; B D Blackhart; V R Pierotti; L Caiati; C Fortier; T Knott; J Scott; R W Mahley; B Levy-Wilson; B J McCarthy
Journal: DNA Date: 1987-08

3. Contribution to the inheritance of the Ag groups. A population genetic study.

Authors: R Bütler; E Brunner; G Morganti
Journal: Vox Sang Date: 1974 Impact factor: 2.144

4. A worldwide population study of the Ag-system haplotypes, a genetic polymorphism of human low-density lipoprotein.

Authors: G Breguet; R Bütler; E Bütler-Brunner; A Sanchez-Mazas
Journal: Am J Hum Genet Date: 1990-03 Impact factor: 11.025

5. Apolipoprotein B amino acid 3611 substitution from arginine to glutamine creates the Ag (h/i) epitope: the polymorphism is not associated with differences in serum cholesterol and apolipoprotein B levels.

Authors: C F Xu; N Nanjee; M J Tikkanen; J K Huttunen; P Pietinen; R Bütler; F Angelico; M Del Ben; B Mazzarella; R Antonio
Journal: Hum Genet Date: 1989-07 Impact factor: 4.132

3 in total

1. New nucleotide sequence data on the EMBL File Server.

Authors:
Journal: Nucleic Acids Res Date: 1991-05-25 Impact factor: 16.971

2. Analysis of DNA diversity by spatial autocorrelation.

Authors: G Bertorelle; G Barbujani
Journal: Genetics Date: 1995-06 Impact factor: 4.562

3. Two amino acid substitutions in apolipoprotein B are in complete allelic association with the antigen group (x/y) polymorphism: evidence for little recombination in the 3' end of the human gene.

Authors: A M Dunning; H H Renges; C F Xu; R Peacock; R Brasseur; G Laxer; M J Tikkanen; R Bütler; N Saha; A Hamsten
Journal: Am J Hum Genet Date: 1992-01 Impact factor: 11.025

3 in total

Identification of the ancestral haplotype for apolipoprotein B suggests an African origin of Homo sapiens sapiens and traces their subsequent migration to Europe and the Pacific.

1. Bsp 12861 restriction fragment length polymorphism detects Ag(c/g) locus of human apolipoprotein B in all 17 persons studied.

2. DNA sequence of the human apolipoprotein B gene.

3. Contribution to the inheritance of the Ag groups. A population genetic study.

4. A worldwide population study of the Ag-system haplotypes, a genetic polymorphism of human low-density lipoprotein.

5. Apolipoprotein B amino acid 3611 substitution from arginine to glutamine creates the Ag (h/i) epitope: the polymorphism is not associated with differences in serum cholesterol and apolipoprotein B levels.

6. Mitochondrial DNA sequences in single hairs from a southern African population.

7. Reconstruction of human evolution: bringing together genetic, archaeological, and linguistic data.

8. HLA-A and B polymorphisms predate the divergence of humans and chimpanzees.

9. Allelic diversification at the class II DQB locus of the mammalian major histocompatibility complex.

10. Evolutionary tree for apes and humans based on cleavage maps of mitochondrial DNA.

1. New nucleotide sequence data on the EMBL File Server.

2. Analysis of DNA diversity by spatial autocorrelation.

3. Two amino acid substitutions in apolipoprotein B are in complete allelic association with the antigen group (x/y) polymorphism: evidence for little recombination in the 3' end of the human gene.