| Literature DB >> 19963378 |
Fabio M Sabbatini1, Romano Di Fabio, Cristiana Griffante, Giorgio Pentassuglia, Laura Zonzini, Sergio Melotto, Giuseppe Alvaro, Anna M Capelli, Lara Pippo, Elisabetta Perdona', Yves St Denis, Silvano Costa, Mauro Corsi.
Abstract
A focused exploration targeting conformationally restricted analogues of Vestipitant, resulted in the discovery of novel, in vitro potent NK(1) antagonists. In particular, two of the compounds reported exhibited a good pharmacokinetic (PK) profile and produced anxiolytic-like effects in the gerbil foot tapping (GFT) in vivo model. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19963378 DOI： 10.1016/j.bmcl.2009.11.078
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823