| Literature DB >> 19963041 |
Milena De Riz1, Daniela Galimberti, Chiara Fenoglio, Laura M Piccio, Diego Scalabrini, Eliana Venturelli, Anna Pietroboni, Mirko Piola, Robert T Naismith, Becky J Parks, Giorgio Fumagalli, Nereo Bresolin, Anne H Cross, Elio Scarpini.
Abstract
Progranulin has recently attracted attention due to the discovery of mutations in its encoding gene (GRN) in several cases of frontotemporal lobar degeneration, but also for a possible role in inflammatory processes. In adult central nervous system, GRN mRNA is expressed in forebrain, olfactory bulbs and spinal cord. Progranulin cerebrospinal fluid (CSF) levels were evaluated in 55 patients with multiple sclerosis (MS) as well as in 35 subjects with non-inflammatory neurological diseases (NIND), 7 individuals with other inflammatory neurological disease (OIND) and 8 controls (CON), matched for ethnic background, gender and age. No statistically significant differences were found in patients compared with either NIND, OIND or CON (P>0.05), even stratifying according to disease subtype or gender. A positive correlation between progranulin CSF levels and age was observed in patients (rho=0.29, P=0.03). According to these data, progranulin does not likely play a major role in the pathogenesis of MS. (c) 2009 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19963041 PMCID： PMC2893414 DOI： 10.1016/j.neulet.2009.12.002
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046