Literature DB >> 19962890

In vitro antitubercular and antimicrobial activities of 1-substituted quinoxaline-2,3(1H,4H)-diones.

P Ramalingam1, S Ganapaty, Ch Babu Rao.   

Abstract

1-((Substituted)methyl)quinoxaline-2,3(1H,4H)-dione (2a-e) and 1-((substituted)acryloyl)quinoxaline-2,3(1H,4H)-dione (4a-c) were synthesized from quinoxaline-2,3(1H,4H)-dione 1 and evaluated for their antimicrobial activities. Results of the antitubercular screening against Mycobacterium tuberculosis H(37)Rv showed that the compounds 2b,3, and 4a were the most effective, with minimum inhibitory concentrations of 8.012, 8.561, and 8.928microg/ml, respectively. All the compounds exhibited significant antibacterial and considerable antifungal activities. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19962890     DOI： 10.1016/j.bmcl.2009.10.026

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

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Journal:  Antimicrob Agents Chemother       Date:  2011-09-26       Impact factor: 5.191

Review 2.  Mannich bases in medicinal chemistry and drug design.

Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

3.  New Conjugates of Quinoxaline as Potent Antitubercular and Antibacterial Agents.

Authors:  Ramalingam Peraman; Rajendran Kuppusamy; Sunil Kumar Killi; Y Padmanabha Reddy
Journal:  Int J Med Chem       Date:  2016-03-08

4.  Anti-Mycobacterium tuberculosis Activity of Esters of Quinoxaline 1,4-Di-N-Oxide.

Authors:  Isidro Palos; Julieta Luna-Herrera; Edgar E Lara-Ramírez; Alejandra Loera-Piedra; Emanuel Fernández-Ramírez; Ma Guadalupe Aguilera-Arreola; Alma D Paz-González; Antonio Monge; Baojie Wan; Scott Franzblau; Gildardo Rivera
Journal:  Molecules       Date:  2018-06-15       Impact factor: 4.411

5.  Nucleophilic Substitution on 2-Monosubstituted Quinoxalines Giving 2,3-Disubstituted Quinoxalines: Investigating the Effect of the 2-Substituent.

Authors:  Ndumiso Thamsanqa Ndlovu; Winston Nxumalo
Journal:  Molecules       Date:  2016-09-30       Impact factor: 4.411

6.  Synthesis and Antiviral Properties against SARS-CoV-2 of Epoxybenzooxocino[4,3-b]Pyridine Derivatives.

Authors:  Alena L Stalinskaya; Nadezhda V Martynenko; Zarina T Shulgau; Alexandr V Shustov; Viktoriya V Keyer; Ivan V Kulakov
Journal:  Molecules       Date:  2022-06-09       Impact factor: 4.927

7.  Synthesis and cytotoxic evaluation of some novel quinoxalinedione diarylamide sorafenib analogues.

Authors:  Mojtaba Khandan; Sedighe Sadeghian-Rizi; Ghadamali Khodarahmi; Farshid Hassanzadeh
Journal:  Res Pharm Sci       Date:  2018-04
  7 in total

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