Literature DB >> 19962794

Asymmetric synthesis of anticancer beta-lactams via Staudinger reaction: utilization of chiral ketene from carbohydrate.

Bimal K Banik1, Indrani Banik, Frederick F Becker.   

Abstract

We describe herein asymmetric synthesis of a novel anticancer beta-lactam following Staudinger reaction with chiral carbohydrate as the ketene component with an achiral imine. The in vitro cytotoxicity studies of these beta-lactams are also reported here. Copyright 2009. Published by Elsevier Masson SAS.

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Year:  2009        PMID: 19962794     DOI: 10.1016/j.ejmech.2009.11.024

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN: 0223-5234            Impact factor:   6.514


  5 in total

1.  Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity.

Authors:  Debasish Bandyopadhyay; Jose C Granados; John D Short; Bimal K Banik
Journal:  Oncol Lett       Date:  2011-10-04       Impact factor: 2.967

2.  Biological Evaluation in Vitro and in Silico of Azetidin-2-one Derivatives as Potential Anticancer Agents.

Authors:  Fabián E Olazaran; Gildardo Rivera; Alondra M Pérez-Vázquez; Cynthia M Morales-Reyes; Aldo Segura-Cabrera; Isaías Balderas-Rentería
Journal:  ACS Med Chem Lett       Date:  2016-11-10       Impact factor: 4.345

3.  Advances in the chemistry of β-lactam and its medicinal applications.

Authors:  Anushree Kamath; Iwao Ojima
Journal:  Tetrahedron       Date:  2012-08-07       Impact factor: 2.457

4.  A personal perspective on medicinal and pharmaceutical chemistry.

Authors:  Bimal K Banik
Journal:  Front Chem       Date:  2014-02-27       Impact factor: 5.221

5.  Stereochemical preference toward oncotarget: Design, synthesis and in vitro anticancer evaluation of diastereomeric β-lactams.

Authors:  Fabián Olazarán-Santibáñez; Debasish Bandyopadhyay; Pilar Carranza-Rosales; Gildardo Rivera; Isaías Balderas-Rentería
Journal:  Oncotarget       Date:  2017-06-06
  5 in total

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