Literature DB >> 19962661

Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity.

Rocio Sotillo1, Juan-Manuel Schvartzman, Robert Benezra.   

Abstract

Mechanisms by which whole chromosome instability lead to tumorigenesis have eluded the cancer research field. In this issue of Cancer Cell, Baker et al. show that CIN induced by a defective mitotic checkpoint, under certain genetic and tissue contexts, leads to accelerated loss of heterozygosity of a tumor suppressor gene.

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Mesh：

Year:  2009        PMID： 19962661      PMCID： PMC5513159          DOI： 10.1016/j.ccr.2009.11.014

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

1.  Cytogenetic and cellular events during radiation-induced thymic lymphomagenesis in the p53 heterozygous (+/-) B10 mouse.

Authors:  K Tanaka; K Watanabe; M Mori; H Kamisaku; H Tsuji; Y Hirabayashi; T Inoue; K Yoshida; S Aizawa
Journal:  Int J Radiat Biol       Date:  2002-03       Impact factor: 2.694

Review 2.  A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy.

Authors:  Ignacio Pérez de Castro; Guillermo de Cárcer; Marcos Malumbres
Journal:  Carcinogenesis       Date:  2007-01-27       Impact factor: 4.944

3.  Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability.

Authors:  Chinthalapally V Rao; Yang-Ming Yang; Malisetty V Swamy; Tongyi Liu; Yuqiang Fang; Radma Mahmood; Meena Jhanwar-Uniyal; Wei Dai
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-14       Impact factor: 11.205

4.  Aneuploidy acts both oncogenically and as a tumor suppressor.

Authors:  Beth A A Weaver; Alain D Silk; Cristina Montagna; Pascal Verdier-Pinard; Don W Cleveland
Journal:  Cancer Cell       Date:  2006-12-28       Impact factor: 31.743

5.  Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.

Authors:  Darren J Baker; Fang Jin; Karthik B Jeganathan; Jan M van Deursen
Journal:  Cancer Cell       Date:  2009-12-08       Impact factor: 31.743

6.  Tumor spectrum analysis in p53-mutant mice.

Authors:  T Jacks; L Remington; B O Williams; E M Schmitt; S Halachmi; R T Bronson; R A Weinberg
Journal:  Curr Biol       Date:  1994-01-01       Impact factor: 10.834

7.  Loss of Apc+ in intestinal adenomas from Min mice.

Authors:  C Luongo; A R Moser; S Gledhill; W F Dove
Journal:  Cancer Res       Date:  1994-11-15       Impact factor: 12.701

8.  Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

Authors:  Irene García-Higuera; Eusebio Manchado; Pierre Dubus; Marta Cañamero; Juan Méndez; Sergio Moreno; Marcos Malumbres
Journal:  Nat Cell Biol       Date:  2008-06-15       Impact factor: 28.824

9.  Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.

Authors:  Karthik Jeganathan; Liviu Malureanu; Darren J Baker; Susan C Abraham; Jan M van Deursen
Journal:  J Cell Biol       Date:  2007-10-15       Impact factor: 10.539
  9 in total
  5 in total

1.  Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.

Authors:  Nicolas Aznar; Krishna K Midde; Ying Dunkel; Inmaculada Lopez-Sanchez; Yelena Pavlova; Arthur Marivin; Jorge Barbazán; Fiona Murray; Ulrich Nitsche; Klaus-Peter Janssen; Karl Willert; Ajay Goel; Miguel Abal; Mikel Garcia-Marcos; Pradipta Ghosh
Journal:  Elife       Date:  2015-06-30       Impact factor: 8.140

2.  Chromosome missegregation causes colon cancer by APC loss of heterozygosity.

Authors:  Darren J Baker; Jan M van Deursen
Journal:  Cell Cycle       Date:  2010-05-27       Impact factor: 4.534

Review 3.  Chromosomal instability as a source of genomic plasticity.

Authors:  Duaa H Al-Rawi; Samuel F Bakhoum
Journal:  Curr Opin Genet Dev       Date:  2022-05-05       Impact factor: 4.665

4.  Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer.

Authors:  Marjaana Pussila; Petri Törönen; Elisabet Einarsdottir; Shintaro Katayama; Kaarel Krjutškov; Liisa Holm; Juha Kere; Päivi Peltomäki; Markus J Mäkinen; Jere Linden; Minna Nyström
Journal:  Carcinogenesis       Date:  2018-05-28       Impact factor: 4.944

5.  Genomic DNA Copy Number Aberrations, Histological Diagnosis, Oral Subsite and Aneuploidy in OPMDs/OSCCs.

Authors:  Patrizio Castagnola; Gabriele Zoppoli; Sergio Gandolfo; Massimiliano Monticone; Davide Malacarne; Gabriella Cirmena; David Brown; Cinzia Aiello; Massimo Maffei; Roberto Marino; Walter Giaretti; Monica Pentenero
Journal:  PLoS One       Date:  2015-11-05       Impact factor: 3.240
  5 in total

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