Literature DB >> 19962231

Antitumor activity of novel fluoro-substituted (-)-epigallocatechin-3-gallate analogs.

Huanjie Yang1, Dong Kui Sun, Di Chen, Qiuzhi Cindy Cui, Yan Yan Gu, Tao Jiang, Wei Chen, Sheng Biao Wan, Q Ping Dou.   

Abstract

Epidemiological studies support the cancer-preventive effects of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG], however, (-)-EGCG is unstable under physiological conditions. Here we report that two novel fluoro-substituted (-)-EGCG analogs inhibited tumor growth with similar potency to that of Pro-EGCG (1) which has improved potency over parental compound (-)-EGCG in human breast cancer MDA-MB-231 xenografts. MDA-MB-231 tumors treated with each fluoro-substituted (-)-EGCG analog showed proteasome inhibition and apoptotic cell death, suggesting that the proteasome might be one of the cellular targets of fluoro-(-)-EGCGs and that proteasome inhibition is partially responsible for the observed antitumor activity. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.

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Year:  2009        PMID： 19962231      PMCID： PMC2854268          DOI： 10.1016/j.canlet.2009.11.006

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  23 in total

Review 1.  The ubiquitin-proteasome system.

Authors:  Dipankar Nandi; Pankaj Tahiliani; Anujith Kumar; Dilip Chandu
Journal:  J Biosci       Date:  2006-03       Impact factor: 1.826

2.  A phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma.

Authors:  Aminah Jatoi; Neil Ellison; Patrick A Burch; Jeff A Sloan; Shaker R Dakhil; Paul Novotny; Winston Tan; Tom R Fitch; Kendrith M Rowland; Charles Y F Young; Patrick J Flynn
Journal:  Cancer       Date:  2003-03-15       Impact factor: 6.860

3.  Synthetic peracetate tea polyphenols as potent proteasome inhibitors and apoptosis inducers in human cancer cells.

Authors:  Deborah Kuhn; Wai Har Lam; Aslamuzzaman Kazi; Kenyon G Daniel; Shuojing Song; Larry M C Chow; Tak Hang Chan; Q Ping Dou
Journal:  Front Biosci       Date:  2005-05-01

4.  A prospective clinical trial of green tea for hormone refractory prostate cancer: an evaluation of the complementary/alternative therapy approach.

Authors:  E Choan; Roanne Segal; Derek Jonker; Shawn Malone; Neil Reaume; Libni Eapen; Victor Gallant
Journal:  Urol Oncol       Date:  2005 Mar-Apr       Impact factor: 3.498

Review 5.  Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death.

Authors:  P J Duriez; G M Shah
Journal:  Biochem Cell Biol       Date:  1997       Impact factor: 3.626

6.  Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study.

Authors:  Saverio Bettuzzi; Maurizio Brausi; Federica Rizzi; Giovanni Castagnetti; Giancarlo Peracchia; Arnaldo Corti
Journal:  Cancer Res       Date:  2006-01-15       Impact factor: 12.701

7.  The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from "Indian winter cherry".

Authors:  Huanjie Yang; Guoqing Shi; Q Ping Dou
Journal:  Mol Pharmacol       Date:  2006-11-08       Impact factor: 4.436

Review 8.  Metabolism of green tea catechins: an overview.

Authors:  Wan Yong Feng
Journal:  Curr Drug Metab       Date:  2006-10       Impact factor: 3.731

Review 9.  Tea polyphenols, their biological effects and potential molecular targets.

Authors:  D Chen; V Milacic; M S Chen; S B Wan; W H Lam; C Huo; K R Landis-Piwowar; Q C Cui; A Wali; T H Chan; Q P Dou
Journal:  Histol Histopathol       Date:  2008-04       Impact factor: 2.303

10.  Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27.

Authors:  M Pagano; S W Tam; A M Theodoras; P Beer-Romero; G Del Sal; V Chau; P R Yew; G F Draetta; M Rolfe
Journal:  Science       Date:  1995-08-04       Impact factor: 47.728
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  13 in total

Review 1.  Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization.

Authors:  Min Shen; Tak Hang Chan; Q Ping Dou
Journal:  Anticancer Agents Med Chem       Date:  2012-10-01       Impact factor: 2.505

2.  A novel prodrug of epigallocatechin-3-gallate: differential epigenetic hTERT repression in human breast cancer cells.

Authors:  Syed M Meeran; Shweta N Patel; Tak-Hang Chan; Trygve O Tollefsbol
Journal:  Cancer Prev Res (Phila)       Date:  2011-03-16

3.  Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells.

Authors:  Di Chen; Sreedhar Pamu; Qiuzhi Cui; Tak Hang Chan; Q Ping Dou
Journal:  Bioorg Med Chem       Date:  2012-03-09       Impact factor: 3.641

Review 4.  EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment.

Authors:  Di Chen; Sheng Biao Wan; Huanjie Yang; Jian Yuan; Tak Hang Chan; Q Ping Dou
Journal:  Adv Clin Chem       Date:  2011       Impact factor: 5.394

Review 5.  Green tea polyphenols as proteasome inhibitors: implication in chemoprevention.

Authors:  H Yang; K Landis-Piwowar; T H Chan; Q P Dou
Journal:  Curr Cancer Drug Targets       Date:  2011-03       Impact factor: 3.428

Review 6.  Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives.

Authors:  D Chen; M Frezza; S Schmitt; J Kanwar; Q P Dou
Journal:  Curr Cancer Drug Targets       Date:  2011-03       Impact factor: 3.428

Review 7.  Chemoprevention of head and neck cancer with green tea polyphenols.

Authors:  Joseph W Kim; A R M Ruhul Amin; Dong M Shin
Journal:  Cancer Prev Res (Phila)       Date:  2010-07-27

Review 8.  Recent advances on tea polyphenols.

Authors:  Jyoti Kanwar; Mujtaba Taskeen; Imthiyaz Mohammad; Congde Huo; Tak Hang Chan; Qing Ping Dou
Journal:  Front Biosci (Elite Ed)       Date:  2012-01-01

Review 9.  Molecular targets of naturopathy in cancer research: bridge to modern medicine.

Authors:  Aamir Ahmad; Kevin R Ginnebaugh; Yiwei Li; Subhash B Padhye; Fazlul H Sarkar
Journal:  Nutrients       Date:  2015-01-06       Impact factor: 5.717

Review 10.  Broad targeting of angiogenesis for cancer prevention and therapy.

Authors:  Zongwei Wang; Charlotta Dabrosin; Xin Yin; Mark M Fuster; Alexandra Arreola; W Kimryn Rathmell; Daniele Generali; Ganji P Nagaraju; Bassel El-Rayes; Domenico Ribatti; Yi Charlie Chen; Kanya Honoki; Hiromasa Fujii; Alexandros G Georgakilas; Somaira Nowsheen; Amedeo Amedei; Elena Niccolai; Amr Amin; S Salman Ashraf; Bill Helferich; Xujuan Yang; Gunjan Guha; Dipita Bhakta; Maria Rosa Ciriolo; Katia Aquilano; Sophie Chen; Dorota Halicka; Sulma I Mohammed; Asfar S Azmi; Alan Bilsland; W Nicol Keith; Lasse D Jensen
Journal:  Semin Cancer Biol       Date:  2015-01-16       Impact factor: 15.707
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