OBJECTIVE: The purpose of the present study was to investigate the electrolyte alterations of submandibular/sublingual saliva in submandibular sialolithiasis patients compared with saliva from healthy controls. DESIGN: Submandibular/sublingual saliva was collected from 10 submandibular sialolithiasis patients and from 10 sex- and age-matched healthy controls. Ion chromatography was performed to determine the concentrations of inorganic cations (potassium, calcium, magnesium, and sodium), inorganic anions (chloride, phosphate, nitrate, and sulphate) and organic anions (thiocyanate, lactate, acetate, and citrate). RESULTS: The calcium concentration was significantly higher in sialolithiasis patients than in controls (P<0.05). In contrast, the levels of magnesium and citrate in the saliva of sialolithiasis patients were significantly reduced compared to the values obtained in controls (P<0.05). No significant differences were detected among other ions. CONCLUSIONS: Our findings indicate that saliva electrolyte composition of sialolithiasis patients is substantially altered with respect to crystallisation mechanisms. Increased calcium ion as a crystallisation substance and decreased magnesium and citrate ions as crystallisation inhibitors may be involved in the etiopathology of calculi formation. Copyright 2009 Elsevier Ltd. All rights reserved.
OBJECTIVE: The purpose of the present study was to investigate the electrolyte alterations of submandibular/sublingual saliva in submandibular sialolithiasispatients compared with saliva from healthy controls. DESIGN: Submandibular/sublingual saliva was collected from 10 submandibular sialolithiasispatients and from 10 sex- and age-matched healthy controls. Ion chromatography was performed to determine the concentrations of inorganic cations (potassium, calcium, magnesium, and sodium), inorganic anions (chloride, phosphate, nitrate, and sulphate) and organic anions (thiocyanate, lactate, acetate, and citrate). RESULTS: The calcium concentration was significantly higher in sialolithiasispatients than in controls (P<0.05). In contrast, the levels of magnesium and citrate in the saliva of sialolithiasispatients were significantly reduced compared to the values obtained in controls (P<0.05). No significant differences were detected among other ions. CONCLUSIONS: Our findings indicate that saliva electrolyte composition of sialolithiasispatients is substantially altered with respect to crystallisation mechanisms. Increased calcium ion as a crystallisation substance and decreased magnesium and citrate ions as crystallisation inhibitors may be involved in the etiopathology of calculi formation. Copyright 2009 Elsevier Ltd. All rights reserved.
Authors: Charlotte Duch Lynggaard; Christian Grønhøj; Robin Christensen; Anne Fischer-Nielsen; Jacob Melchiors; Lena Specht; Elo Andersen; Jann Mortensen; Peter Oturai; Gry Hoffmann Barfod; Eva Kannik Haastrup; Michael Møller-Hansen; Mandana Haack-Sørensen; Annette Ekblond; Jens Kastrup; Siri Beier Jensen; Christian von Buchwald Journal: Stem Cells Transl Med Date: 2022-05-27 Impact factor: 7.655