OBJECTIVES: The long pentraxin PTX3 is a promising marker of disease severity in severely ill patients. In order to identify patients warranting critical care as quickly as possible, we investigated the value of PTX3 as a biomarker for disease severity in patients presenting with fever at the emergency department. METHODS: Levels of PTX3 were measured in 211 febrile patients at the emergency and the levels were linked to markers of disease severity including admittance to a special care unit, bloodstream infection and congestive heart failure. RESULTS: In comparison to median baseline levels of 2.30 ng/ml (interquartile range 1.66-3.67 ng/ml), levels of PTX3 were significantly elevated in patients admitted to the intensive-/medium care unit (median value 44.4 ng/ml, interquartile range 13.6-105.9 ng/ml) and in patients referred to the ward (median value 14.2 ng/ml, interquartile range 7.01-25.1 ng/ml). In addition, PTX3 was associated with duration of hospital stay and acute congestive heart failure. The levels were predictive for bloodstream infection (AUC=0.71; 95% CI 0.62-0.81). CONCLUSIONS: PTX3 may be a useful marker for differentiation of patients with severe disease in patients presenting with fever to the emergency department. Copyright 2009 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
OBJECTIVES: The long pentraxin PTX3 is a promising marker of disease severity in severely ill patients. In order to identify patients warranting critical care as quickly as possible, we investigated the value of PTX3 as a biomarker for disease severity in patients presenting with fever at the emergency department. METHODS: Levels of PTX3 were measured in 211 febrile patients at the emergency and the levels were linked to markers of disease severity including admittance to a special care unit, bloodstream infection and congestive heart failure. RESULTS: In comparison to median baseline levels of 2.30 ng/ml (interquartile range 1.66-3.67 ng/ml), levels of PTX3 were significantly elevated in patients admitted to the intensive-/medium care unit (median value 44.4 ng/ml, interquartile range 13.6-105.9 ng/ml) and in patients referred to the ward (median value 14.2 ng/ml, interquartile range 7.01-25.1 ng/ml). In addition, PTX3 was associated with duration of hospital stay and acute congestive heart failure. The levels were predictive for bloodstream infection (AUC=0.71; 95% CI 0.62-0.81). CONCLUSIONS:PTX3 may be a useful marker for differentiation of patients with severe disease in patients presenting with fever to the emergency department. Copyright 2009 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
Authors: Matti Vänskä; Irma Koivula; Sari Hämäläinen; Kari Pulkki; Tapio Nousiainen; Esa Jantunen; Auni Juutilainen Journal: Haematologica Date: 2011-09 Impact factor: 9.941
Authors: T K Outinen; S Mäkelä; H Huhtala; M Hurme; S Meri; I Pörsti; J Sane; A Vaheri; J Syrjänen; J Mustonen Journal: Eur J Clin Microbiol Infect Dis Date: 2011-09-07 Impact factor: 3.267
Authors: Reetta Huttunen; Mikko Hurme; Janne Aittoniemi; Heini Huhtala; Risto Vuento; Janne Laine; Juulia Jylhävä; Jaana Syrjänen Journal: PLoS One Date: 2011-03-10 Impact factor: 3.240
Authors: Raija Uusitalo-Seppälä; Reetta Huttunen; Janne Aittoniemi; Pertti Koskinen; Aila Leino; Tero Vahlberg; Esa M Rintala Journal: PLoS One Date: 2013-01-14 Impact factor: 3.240
Authors: Marco Bo Hansen; Lars Simon Rasmussen; Peter Garred; Daniel Bidstrup; Martin Bruun Madsen; Ole Hyldegaard Journal: Crit Care Date: 2016-02-15 Impact factor: 9.097