AIM: To investigate the effects of a novel Leukotriene B(4) receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more significantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreatment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver ischemia-reperfusion injury.
AIM: To investigate the effects of a novel Leukotriene B(4) receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more significantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreatment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver ischemia-reperfusion injury.
Authors: F J Garcia-Criado; J M Palma-Vargas; J J Valdunciel-Garcia; A H Toledo; K Misawa; A Gomez-Alonso; L H Toledo-Pereyra Journal: Transplantation Date: 1997-08-27 Impact factor: 4.939
Authors: F J Garcia-Criado; J M Palma-Vargas; J J Valdunciel-Garcia; A Gomez-Alonso; O Srivastava; A Ezrin; M B Anderson; L H Toledo-Pereyra Journal: J Surg Res Date: 1997-07-01 Impact factor: 2.192
Authors: Sebastian Pratschke; Michael Eder; Michael Heise; Silvio Nadalin; Andreas Pascher; Peter Schemmer; Marcus N Scherer; Frank Ulrich; Heiner Wolters; Karl-Walter Jauch; Dirk Wöhling; Martin K Angele Journal: Transplant Res Date: 2013-03-04