PURPOSE: Studies investigating the association between genetic polymorphism of glutathione S-transferase T1 (GSTT1) and gastric cancer risk have reported conflicting results. Therefore, we conducted this meta-analysis to provide more precise evidence. METHODS: We searched the databases Medline, PubMed, Embase, and China National Knowledge Infrastructure up to July 30, 2009. Thirty-six studies with 4,357 gastric cancer cases and 9,796 controls were selected. Odds ratio (OR) and 95% confidence intervals (CI) were calculated based on fixed- and random-effects models. RESULTS: The combined results based on all studies showed there was a significant link between GSTT1 null genotype and gastric cancer risk (OR = 1.14, 95%CI = 1.01-1.28). In subgroup analysis stratified on the basis of ethnic group, we also observed positive association between GSTT1 polymorphism and gastric cancer risk among Caucasians (non-Europeans + non-Americans), but not among East Asians. When stratifying by control source, the overall ORs for population- and hospital-based studies were 1.09 (95%CI = 0.94-1.28) and 1.17 (95%CI = 1.03-1.34), respectively. Subjects with both GSTM1 and GSTT1 negative genotypes had increased gastric cancer risk compared with those who had nonnull genotypes of both GST genes. Subgroup analyses for Helicobacter pylori infection and smoking habit did not reveal any significant association between GSTT1 polymorphism and gastric cancer development. CONCLUSIONS: This meta-analysis suggests that GSTT1 gene polymorphism may be not associated with increased gastric cancer risk among Europeans, Americans, and East Asians. More large-scale studies based on the same racial group are needed.
PURPOSE: Studies investigating the association between genetic polymorphism of glutathione S-transferase T1 (GSTT1) and gastric cancer risk have reported conflicting results. Therefore, we conducted this meta-analysis to provide more precise evidence. METHODS: We searched the databases Medline, PubMed, Embase, and China National Knowledge Infrastructure up to July 30, 2009. Thirty-six studies with 4,357 gastric cancer cases and 9,796 controls were selected. Odds ratio (OR) and 95% confidence intervals (CI) were calculated based on fixed- and random-effects models. RESULTS: The combined results based on all studies showed there was a significant link between GSTT1 null genotype and gastric cancer risk (OR = 1.14, 95%CI = 1.01-1.28). In subgroup analysis stratified on the basis of ethnic group, we also observed positive association between GSTT1 polymorphism and gastric cancer risk among Caucasians (non-Europeans + non-Americans), but not among East Asians. When stratifying by control source, the overall ORs for population- and hospital-based studies were 1.09 (95%CI = 0.94-1.28) and 1.17 (95%CI = 1.03-1.34), respectively. Subjects with both GSTM1 and GSTT1 negative genotypes had increased gastric cancer risk compared with those who had nonnull genotypes of both GST genes. Subgroup analyses for Helicobacter pylori infection and smoking habit did not reveal any significant association between GSTT1 polymorphism and gastric cancer development. CONCLUSIONS: This meta-analysis suggests that GSTT1 gene polymorphism may be not associated with increased gastric cancer risk among Europeans, Americans, and East Asians. More large-scale studies based on the same racial group are needed.
Authors: M Deakin; J Elder; C Hendrickse; D Peckham; D Baldwin; C Pantin; N Wild; P Leopard; D A Bell; P Jones; H Duncan; K Brannigan; J Alldersea; A A Fryer; R C Strange Journal: Carcinogenesis Date: 1996-04 Impact factor: 4.944
Authors: Carmen Martínez; Felipe Martín; Juana M Fernández; Elena García-Martín; Javier Sastre; Manuel Díaz-Rubio; José Ag Agúndez; José M Ladero Journal: Pharmacogenomics Date: 2006-07 Impact factor: 2.533
Authors: Antonio Agudo; Núria Sala; Guillem Pera; Gabriel Capellá; Antonio Berenguer; Nadia García; Domenico Palli; Heiner Boeing; Giuseppe Del Giudice; Calogero Saieva; Fatima Carneiro; Franco Berrino; Carlotta Sacerdote; Rosario Tumino; Salvatore Panico; Göran Berglund; Henrik Simán; Roger Stenling; Göran Hallmans; Carmen Martínez; Roberto Bilbao; Aurelio Barricarte; Carmen Navarro; José R Quirós; Naomi Allen; Tim Key; Sheila Bingham; Kay-Tee Khaw; Jakob Linseisen; Gabriele Nagel; Kim Overvad; Anne Tjonneland; Anja Olsen; H Bas Bueno-de-Mesquita; Hendriek C Boshuizen; Petra H Peeters; Mattijs E Numans; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Antonia Trichopoulou; Eiliv Lund; Johan Offerhaus; Mazda Jenab; Pietro Ferrari; Teresa Norat; Elio Riboli; Carlos A González Journal: Cancer Epidemiol Biomarkers Prev Date: 2006-12 Impact factor: 4.254