Literature DB >> 19959360

SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists.

Gunther Zischinsky1, Frank Osterkamp, Doerte Vossmeyer, Grit Zahn, Dirk Scharn, Ariane Zwintscher, Roland Stragies.   

Abstract

Recently, a new class of selective integrin alpha5beta1inhibitors consisting of a heterocyclic based scaffold was published. Herein the SAR and pharmacokinetic profiles of N-phenyl piperidine derivatives are described. Copyright 2009 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19959360     DOI： 10.1016/j.bmcl.2009.11.030

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.

Authors:  Aparna Sundaram; Chun Chen; Nilgun Isik Reed; Sean Liu; Seul Ki Yeon; Joel McIntosh; You-Zhi Tang; Hyunjun Yang; Marc Adler; Richard Beresis; Ian B Seiple; Dean Sheppard; William F DeGrado; Hyunil Jo
Journal:  Bioorg Med Chem Lett       Date:  2020-09-29       Impact factor: 2.823

2.  Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors.

Authors:  Florence Schaffner; Anne Marie Ray; Monique Dontenwill
Journal:  Cancers (Basel)       Date:  2013-01-15       Impact factor: 6.639
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.