| Literature DB >> 19959180 |
Abstract
The function of the immune system declines with age, leading to an increased occurrence and severity of infectious diseases and a decreased response to vaccines. As the thymus gradually loses its ability to replenish the population of naïve T cells, the memory and effector T cells increase in number and dominate the repertoire. The changes in the naïve and memory T cell pool that occur with ageing in man are discussed here, along with a brief update of the knowledge of B cell populations in the elderly. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
Mesh：
Year: 2009 PMID： 19959180 DOI： 10.1016/j.jcpa.2009.10.002
Source DB: PubMed Journal: J Comp Pathol ISSN： 0021-9975 Impact factor: 1.311